5-(2-Ethoxyphenyl)-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

Base Information

Chemical Name:5-(2-Ethoxyphenyl)-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
CAS No.:139756-30-2
Molecular Formula:C16H18N4O2
Molecular Weight:298.345
Hs Code.:
Mol file:139756-30-2.mol

Synonyms:5-(2-Ethoxyphenyl)-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

Suppliers and Price of 5-(2-Ethoxyphenyl)-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-(2-Ethoxyphenyl)-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
25mg
$ 140.00

American Custom Chemicals Corporation
5-(2-ETHOXYPHENYL)-3-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE 95.00%
50MG
$ 1871.10

American Custom Chemicals Corporation
5-(2-ETHOXYPHENYL)-3-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE 95.00%
5MG
$ 774.40

Total 6 raw suppliers

Chemical Property of 5-(2-Ethoxyphenyl)-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

Chemical Property:

Melting Point:250-252°C
PSA：83.66000
Density:1.323g/cm³
LogP:2.66440
Storage Temp.:Refrigerator
Solubility.:Dichloromethane, DMF, DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

95+% ^*data from raw suppliers

5-(2-Ethoxyphenyl)-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Potent PDE inhibitor scaffold with in vivo activity. Intermediate for the preparation of Desmethylsildenafil.

Technology Process of 5-(2-Ethoxyphenyl)-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

There total 11 articles about 5-(2-Ethoxyphenyl)-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 139756-30-2
5-(2-ethoxyphenyl)-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

Guidance literature:

Reference yield: 16.0%

: 139756-10-8
4-(2-ethoxybenzamido)-3-n-propyl-1H-pyrazolo-5-carboxamide

: 139756-30-2
5-(2-ethoxyphenyl)-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

Guidance literature:

Reference yield:

: 76424-47-0
3-n-propyl-1H-pyrazolo-5-carboxylic acid

: 139756-30-2
5-(2-ethoxyphenyl)-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: HNO₃; H₂SO₄

2: NH₃

3: SnCl₂

4: NEt₃; DMAP / CH₂Cl₂

5: NaOH / ethanol

With dmap; sodium hydroxide; sulfuric acid; ammonia; nitric acid; triethylamine; tin(ll) chloride; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.05.090