4-chloro-loratadine

Base Information

• Chemical Name: 4-chloro-loratadine
• CAS No.: 165739-83-3
• Molecular Formula: C₂₂H₂₂Cl₂N₂O₂
• Molecular Weight: 417.335
• Mol file: 165739-83-3.mol

Synonyms:4-chloro-loratadine;4-(4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic Acid Ethyl Ester;Loratadine EP IMpurity C;1-Piperidinecarboxylic acid, 4- (4,8-dichloro-5,6-dihydro-11H- benzo[5,6]cyclohepta[1,2-b] pyridin-11-ylidene)-, ethyl ester;Loratadine EP Impurity C ( USP RC G )

Chemical Property of 4-chloro-loratadine

Chemical Property:

• Boiling Point: 553.2±50.0 °C(Predicted)
• PKA: 2.83±0.20(Predicted)
• PSA: 45.33000
• Density: 1.322±0.06 g/cm3(Predicted)
• LogP: 5.13530
• Storage Temp.: -20°C Freezer
• Solubility.: Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

4-ChloroLoratadine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro Loratadine is an impurity of Loratadine (L469575). 4-Chloro Loratadine (Loratadine EP Impurity C) is an impurity of Loratadine (L469575).

Technology Process of 4-chloro-loratadine

There total 1 articles about 4-chloro-loratadine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(8-chloro-11-(1-(ethoxycarbonyl)piperidin-4-ylidene)-6,11-dihydro-5Hbenzo[5,6]cyclohepta[1,2-b]pyridin-4-yl)diphenyl(6-(trifluoromethyl)pyridin-3-yl)phosphonium trifluoromethanesulfonate → ethyl 4-(4,8-dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate (165739-83-3)

Guidance literature:

With lithium chloride; In 1,4-dioxane; at 80 ℃; for 24h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.0c04674

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