Indoline, 3a,6,7,7a-tetrahydro- (6CI)

Base Information

• Chemical Name: Indoline, 3a,6,7,7a-tetrahydro- (6CI)
• CAS No.: 100859-68-5
• Molecular Formula: C8H13N
• Molecular Weight: 123.2
• Mol file: 100859-68-5.mol

Synonyms:Indoline, 3a,6,7,7a-tetrahydro- (6CI)

Chemical Property of Indoline, 3a,6,7,7a-tetrahydro- (6CI)

Chemical Property:

• PSA: 12.03000
• LogP: 1.64330

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Indoline, 3a,6,7,7a-tetrahydro- (6CI)

There total 2 articles about Indoline, 3a,6,7,7a-tetrahydro- (6CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-ethoxy-ethyl)-4-methoxy-cyclohexylamine (100535-43-1) → 2,3,3a,6,7,7a-hexahydro-indole (100859-68-5)

Guidance literature:

With hydrogen bromide; at 150 ℃; Erwaermen des Reaktionsprodukts mit wss. Natronlauge;

DOI:10.1021/jo01100a005

Reference yield:

5-(2-ethoxy-ethyl)-1-methoxy-4-nitro-cyclohexene (100401-22-7) → 2,3,3a,6,7,7a-hexahydro-indole (100859-68-5)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium/charcoal; ethanol / Hydrogenation

2: aqueous hydrobromic acid / 150 °C / Erwaermen des Reaktionsprodukts mit wss. Natronlauge

With palladium on activated charcoal; ethanol; hydrogen bromide;

DOI:10.1021/jo01100a005

upstream raw materials:

2-(2-ethoxy-ethyl)-4-methoxy-cyclohexylamine

5-(2-ethoxy-ethyl)-1-methoxy-4-nitro-cyclohexene