METHYL 3-AMINO-5-HYDROXYPYRAZINE-2-CARBOXYLATE

Base Information

• Chemical Name: METHYL 3-AMINO-5-HYDROXYPYRAZINE-2-CARBOXYLATE
• CAS No.: 1503-03-3
• Molecular Formula: C₆H₇N₃O₃
• Molecular Weight: 169.14
• Hs Code.: 2933990090
• Mol file: 1503-03-3.mol

Synonyms:METHYL 3-AMINO-5-HYDROXYPYRAZINE-2-CARBOXYLATE;3-AMino-5-oxo-4,5-dihydro-pyrazine-2-carboxylic acid Methyl ester

Chemical Property of METHYL 3-AMINO-5-HYDROXYPYRAZINE-2-CARBOXYLATE

Chemical Property:

• Melting Point: 220-260 °C (decomp)
• PKA: 9.54±0.60(Predicted)
• PSA: 98.07000
• Density: 1.58±0.1 g/cm3(Predicted)
• LogP: -0.28010

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-5-hydroxy-pyrazine-2-carboxylicacidmethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of METHYL 3-AMINO-5-HYDROXYPYRAZINE-2-CARBOXYLATE

There total 3 articles about METHYL 3-AMINO-5-HYDROXYPYRAZINE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyl 3-amino-2-pyrazinecarboxylate (16298-03-6) → 3-amino-5-oxy-pyrazine-2-carboxylic acid methyl ester (1503-03-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; for 1.33333h; Reflux;

Reference yield:

Methyl 3-amino-2-pyrazinecarboxylate (16298-03-6) → 5-Hydroxy-3-amino-2-methoxycarbonyl-pyrazin (1503-03-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid;

DOI:10.1016/j.bmcl.2009.03.029

Reference yield:

→ 5-Hydroxy-3-amino-2-methoxycarbonyl-pyrazin (1503-03-3)

Guidance literature:

2-Hydroxy-3-chlor-6-amino-5-methoxycarbonyl-pyrazin, MgO (Me.), H2/Pd-C;

DOI:10.1021/jm00313a014

upstream raw materials:

Methyl 3-amino-2-pyrazinecarboxylate

Downstream raw materials:

3-amino-5-chloro-pyrazine-2-carboxylic acid methyl ester

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