3-oxa-1,8-diazaspiro[4.5]decan-2-one

Base Information

• Chemical Name: 3-oxa-1,8-diazaspiro[4.5]decan-2-one
• CAS No.: 945947-99-9
• Molecular Formula: C₇H₁₂N₂O₂
• Molecular Weight: 156.184
• Mol file: 945947-99-9.mol

Synonyms:3-oxa-1,8-diazaspiro[4.5]decan-2-one;3 - oxa - 1,8 - diazaspiro[4.5]decan - 2 - one 945892-90-0 HCl

Chemical Property of 3-oxa-1,8-diazaspiro[4.5]decan-2-one

Chemical Property:

• Boiling Point: 408.1±45.0 °C (760 mmHg)
• PSA: 50.36000
• Density: 1.23±0.1 g/cm3 (20 °C, 760 mmHg)
• LogP: 0.50600
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

3-Oxa-1,8-diazaspiro[4.5]decan-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-oxa-1,8-diazaspiro[4.5]decan-2-one

There total 3 articles about 3-oxa-1,8-diazaspiro[4.5]decan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-benzyl-3-oxa-1,8-diazaspiro[4.5]decan-2-one (945892-89-7) → 3-oxa-1,8-diazaspiro[4.5]decan-2-one (945947-99-9)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; methanol; at 20 ℃;

Reference yield:

1-benzyl-4-amino-4-piperidinecarboxylic acid (39143-25-4) → 3-oxa-1,8-diazaspiro[4.5]decan-2-one (945947-99-9)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2: dichloromethane / 2 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / 1,4-dioxane; methanol / 50 °C

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

DOI:10.1021/acs.jmedchem.5b01685

Reference yield:

(4-amino-1-benzyl-piperidin-4-yl)-methanol (312928-52-2) → 3-oxa-1,8-diazaspiro[4.5]decan-2-one (945947-99-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 2 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / 1,4-dioxane; methanol / 50 °C

With palladium 10% on activated carbon; hydrogen; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.1021/acs.jmedchem.5b01685

upstream raw materials:

8-benzyl-3-oxa-1,8-diazaspiro[4.5]decan-2-one

1-benzyl-4-amino-4-piperidinecarboxylic acid

(4-amino-1-benzyl-piperidin-4-yl)-methanol