N-benzyl-5-iodopyridin-2-aMine

Base Information

• Chemical Name: N-benzyl-5-iodopyridin-2-aMine
• CAS No.: 1125410-03-8
• Molecular Formula: C12H11IN2
• Molecular Weight: 310.13361
• Hs Code.: 2933399990
• Mol file: 1125410-03-8.mol

Synonyms:N-benzyl-5-iodopyridin-2-aMine;5-Iodo-2(Benzylamino)pyridine

Chemical Property of N-benzyl-5-iodopyridin-2-aMine

Chemical Property:

• PSA: 28.15000
• LogP: 2.72020

Purity/Quality:

98% ^*data from raw suppliers

5-IODO-2(BENZYLAMINO)PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-benzyl-5-iodopyridin-2-aMine

There total 3 articles about N-benzyl-5-iodopyridin-2-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-amino-5-iodopyridine (20511-12-0) + benzyl alcohol (100-51-6,185532-71-2) → N-benzyl-5-iodopyridin-2-amine (1125410-03-8)

Guidance literature:

With zinc(II) nitrate hexahydrate; potassium tert-butylate; In toluene; at 140 ℃; for 36h; Sealed tube; Inert atmosphere; Schlenk technique;

DOI:10.1002/adsc.202000499

Reference yield: 68.0%

2-amino-5-iodopyridine (20511-12-0) + toluene (108-88-3,15644-74-3,16713-13-6) → N-benzyl-5-iodopyridin-2-amine (1125410-03-8)

Guidance literature:

With di-tert-butyl peroxide; copper; In neat (no solvent); at 120 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1039/d0ob00491j

Reference yield:

2-bromo-5-iodo-pyridine (73290-22-9) + benzylamine (100-46-9) → N-benzyl-5-iodopyridin-2-amine (1125410-03-8)

Guidance literature:

With 2-[(dimethylamino)methyl]-1-thiophenolato-copper(I); potassium carbonate; In dimethyl sulfoxide; at 160 ℃; for 16h; chemoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2010.09.019

upstream raw materials:

2-bromo-5-iodo-pyridine

benzylamine

2-amino-5-iodopyridine

toluene

Downstream raw materials:

N-(5-phenylsulfanylpyridin-2-yl)benzylamine

Refernces

• 1、 Sankar, Velayudham,Kathiresan, Murugavel,Sivakumar, Bitragunta,Mannathan, Subramaniyan. "Zinc-Catalyzed N-Alkylation of Aromatic Amines with Alcohols: A Ligand-Free Approach". supporting information. p. 4409 - 4414. Retrieved 2020/09/01.