ProHance

Base Information

Chemical Name:ProHance
CAS No.:120066-54-8
Molecular Formula:C17H29GdN4O7
Molecular Weight:558.69
Hs Code.:2942000000
Metabolomics Workbench ID:145335
NCI Thesaurus Code:C65796
RXCUI:25483
Wikipedia:Gadoteridol
Mol file:120066-54-8.mol

Synonyms:gadolinium 1,4,7-tris(carboxymethyl)-10-(2'-hydroxypropyl)-1,4,7,10-tetraazacyclododecane;gadolinium 1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane;gadolinium HP-DO3A;gadoteridol;Gd(DO3A);Gd-HP-D03A;Gd-HP-DO3A;Gd-HPDO3A;Gd-hydroxypropyl-D03A;GdHPDO3A;Prohance;SQ 32,692;SQ 32692;SQ-32692

Suppliers and Price of ProHance

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Alfa Aesar
3-(3-Fluorophenylsulfamoyl)benzeneboronic acid, 97%
250mg
$ 88.40

Alfa Aesar
2-Chloro-5-(cyclohexylcarbamoyl)benzeneboronic acid, 97%
250mg
$ 88.40

Alfa Aesar
3-(4-Fluorophenylsulfamoyl)benzeneboronic acid, 97%
250mg
$ 88.40

Alfa Aesar
5-(2-Bromophenylcarbamoyl)-2-chlorobenzeneboronic acid, 97%
250mg
$ 88.40

Alfa Aesar
2-Chloro-5-(2-fluoro-5-methylphenylcarbamoyl)benzeneboronic acid, 97%
250mg
$ 88.40

Alfa Aesar
2-Chloro-4-(4-morpholinylcarbonyl)benzeneboronic acid, 97%
250mg
$ 88.40

Alfa Aesar
2-Chloro-4-(2-fluoro-5-nitrophenylcarbamoyl)benzeneboronic acid, 97%
250mg
$ 88.40

Alfa Aesar
2-Chloro-5-(3-chloro-4-fluorophenylcarbamoyl)benzeneboronic acid, 97%
250mg
$ 88.40

Alfa Aesar
2-Chloro-5-(2,5-dichlorophenylcarbamoyl)benzeneboronic acid, 97%
250mg
$ 88.40

Alfa Aesar
2-Chloro-5-(2,4-difluorophenylcarbamoyl)benzeneboronic acid, 97%
250mg
$ 88.40

Total 86 raw suppliers

Chemical Property of ProHance

Chemical Property:

Vapor Pressure:1.04E-20mmHg at 25°C
Melting Point:>225oC
Boiling Point:668.2 °C at 760 mmHg
Flash Point:357.9 °C
PSA：101.09000
LogP:-2.14850
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:0
Exact Mass:562.15121
Heavy Atom Count:29
Complexity:494

Purity/Quality:

99%, ^*data from raw suppliers

3-(3-Fluorophenylsulfamoyl)benzeneboronic acid, 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn,T,N,Xi
Hazard Codes:Xn,T,N,Xi
Statements: 22-25-36-50-43-41
Safety Statements: 45-26-61-36/37-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(CN1CCN(CCN(CCN(CC1)CC(=O)O)CC(=O)O)CC(=O)O)O.[Gd+3]
Recent ClinicalTrials:A Study to Compare How Well Gadoquatrane Works and Its Safety With an Already Available Contrast Agent for MRI in People With Known or Suspected Brain or Spinal Cord-related Problems
Recent EU Clinical Trials:Prospective evaluation of potential effects of repeated gadolinium-based contrast agent (GBCA) administrations of the same GBCA on motor and cognitive functions in neurologically normal adults in comparison to a non-GBCA exposed control group—ODYSSEY
Recent NIPH Clinical Trials:Advanced neuroimaging protocol, including 3T MRI with triple-dose gadoteridol administration, for histopathological characterization of glioma and prediction of the patient's prognosis
Uses Diagnostic aid (paramagnetic). Gadoteridol is used as an MRI contrast chelating agent.

Technology Process of ProHance

There total 3 articles about ProHance which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: gadolinium(III) oxide

: 120041-08-9
1,4,7-tris(carboxymethyl)-10-(2'-hydroxypropyl)-1,4,7,10-tetraazacyclododecane

: 120066-54-8
gadoteridol

Guidance literature:: In water; at 85 ℃;

Reference yield: 25.0%

: gadolinium(III) acetate hydrate

: 120041-08-9
1,4,7-tris(carboxymethyl)-10-(2'-hydroxypropyl)-1,4,7,10-tetraazacyclododecane

: 120066-54-8
gadoteridol

Guidance literature:: With hydrogenchloride; In water; at 20 ℃; for 12h; pH=4 - 6.5; Inert atmosphere;

Reference yield:

: 10138-52-0
gadolinium(III) chloride

: 120041-08-9
1,4,7-tris(carboxymethyl)-10-(2'-hydroxypropyl)-1,4,7,10-tetraazacyclododecane

: 120066-54-8
gadoteridol

Guidance literature:: In water; in lightly buffered medium (sodium acetate/acetic acid), 25.0°C +/- 0.1°C, ionic strength 1.0 (NaCl); not isolated; monitoring by UV; Kinetics;