(S)-Methyl 3-amino-3-(4-bromophenyl)propanoate hydrochloride

Base Information

• Chemical Name: (S)-Methyl 3-amino-3-(4-bromophenyl)propanoate hydrochloride
• CAS No.: 1245606-63-6
• Molecular Formula: C10H13BrClNO2
• Molecular Weight: 294.576
• Mol file: 1245606-63-6.mol

Synonyms:(S)-Methyl 3-amino-3-(4-bromophenyl)propanoate hydrochloride

Chemical Property of (S)-Methyl 3-amino-3-(4-bromophenyl)propanoate hydrochloride

Chemical Property:

• PSA: 52.32000
• LogP: 3.51430
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

(S)-Methyl3-amino-3-(4-bromophenyl)propanoatehydrochloride 95+% ^*data from reagent suppliers

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Technology Process of (S)-Methyl 3-amino-3-(4-bromophenyl)propanoate hydrochloride

There total 2 articles about (S)-Methyl 3-amino-3-(4-bromophenyl)propanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(3S)-3-(4-bromophenyl)-3-{[(tert-butoxy)carbonyl]amino}propanoic acid (261165-06-4) → (S)-1-(4-bromophenyl)-3-methoxy-3-oxopropan-1-amine hydrochloride (1245606-63-6,845908-98-7)

Guidance literature:

With hydrogenchloride; In methanol; at 0 - 20 ℃; for 16h;

Reference yield: 90.0%

(Z)-1-(4-bromophenyl)-3-methoxy-3-oxoprop-1-en-1-amine hydrochloride (1245606-55-6) → (S)-1-(4-bromophenyl)-3-methoxy-3-oxopropan-1-amine hydrochloride (1245606-63-6,845908-98-7)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,1'-bis[(S)-4,5-dihydro-3H-binaphtho[2,1-c:1',2'-e]phosphino]ferrocene; hydrogen; In methanol; dichloromethane; at 20 ℃; for 12h; under 38002.6 Torr; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ja105674y

Reference yield: 100.0%

(S)-1-(4-bromophenyl)-3-methoxy-3-oxopropan-1-amine hydrochloride (1245606-63-6,845908-98-7) + (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid (13726-69-7,946610-68-0) → tert-butyl (2S,4R)-2-{[(1S)-1-(4-bromophenyl)-3-methoxy-3-oxopropyl]carbamoyl}-4-hydroxypyrrolidine-1-carboxylate

Guidance literature:

(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

(S)-1-(4-bromophenyl)-3-methoxy-3-oxopropan-1-amine hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at -30 - 20 ℃; for 2h;

upstream raw materials:

(Z)-1-(4-bromophenyl)-3-methoxy-3-oxoprop-1-en-1-amine hydrochloride

(3S)-3-(4-bromophenyl)-3-{[(tert-butoxy)carbonyl]amino}propanoic acid

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