5-BroMo-1,1,3,3-tetraMethylisoindoline

Base Information

• Chemical Name: 5-BroMo-1,1,3,3-tetraMethylisoindoline
• CAS No.: 221368-74-7
• Molecular Formula: C12H16BrN
• Molecular Weight: 254.17
• Mol file: 221368-74-7.mol

Synonyms:5-BroMo-1,1,3,3-tetraMethylisoindoline

Chemical Property of 5-BroMo-1,1,3,3-tetraMethylisoindoline

Chemical Property:

• PSA: 12.03000
• LogP: 3.85130
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

≥99% ^*data from raw suppliers

5-Bromo-1,1,3,3-tetramethylisoindoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BroMo-1,1,3,3-tetraMethylisoindoline

There total 5 articles about 5-BroMo-1,1,3,3-tetraMethylisoindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-benzyl-1,1,3,3-tetramethylisoindoline (82894-83-5) → 5-bromo-1,1,3,3-tetramethylisoindoline (221368-74-7)

Guidance literature:

With aluminum (III) chloride; bromine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1002/ejoc.201201551

Reference yield:

C19H21Br2N + 5-bromo-1,1,3,3-tetramethylisoindoline (705265-55-0) → 5-bromo-1,1,3,3-tetramethylisoindoline (221368-74-7) + 5,6-dibromo-1,1,3,3-tetramethylisoindoline (221368-76-9)

Guidance literature:

C₁₉H₂₁Br₂N; 5-bromo-1,1,3,3-tetramethylisoindoline; With sulfuric acid; water;

With sodium hydroxide; In water; Product distribution / selectivity;

Reference yield:

phthalic anhydride (85-44-9) → 5-bromo-1,1,3,3-tetramethylisoindoline (221368-74-7)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 1 h / Reflux

2: toluene / 4 h / Reflux

3: bromine; aluminum (III) chloride / dichloromethane / 1 h / 0 °C

With aluminum (III) chloride; bromine; acetic acid; In dichloromethane; toluene; 2: |Grignard Reaction;

DOI:10.1002/ejoc.201201551

upstream raw materials:

2,5-dibromo-1,1,3,3-tetramethylisoindoline

5-bromo-1,1,3,3-tetramethylisoindoline

phthalic anhydride

N-benzylphthalimide

Refernces

• 1、 -. "PROFLUORESCENT NITROXIDE COMPOUNDS". Page/Page column 36. . Retrieved 2010/11/28.