Chemical Property of Akt Inhibitor X
Chemical Property:
- PSA：15.71000
- LogP:6.57280
- Sensitive.:Light Sensitive & Hygroscopic
- Solubility.:Soluble in DMSO
- Water Solubility.:Soluble to 100mM in water or DMSO
- Purity/Quality:
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97% *data from raw suppliers
10-DEBCHydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
Akt functions as a key component in multiple signaling pathways to promote cell survival by mediating resistance to apoptosis. Akt inhibitor X is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt with an IC50 value of 1-2 μM. Akt Inhibitor X has been shown to block IGF-1-stimulated nuclear translocation of Akt in Rh1 cells and to inhibit the growth of Rh1, Rh18, and Rh30 cells with IC50 values of 2-5 μM. Inhibition of Akt phosphorylation by 5 μM of Akt Inhibitor X strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis.
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Uses
Akt Inhibitor X is used as a cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity.
