(2S,3S)-3-(Boc-aMino)-2-Methyl-3-phenylpropionic acid

Base Information

• Chemical Name: (2S,3S)-3-(Boc-aMino)-2-Methyl-3-phenylpropionic acid
• CAS No.: 926308-22-7
• Molecular Formula: C15H21NO4
• Molecular Weight: 279.33154
• Hs Code.: 2924299090
• Mol file: 926308-22-7.mol

Synonyms:(2S,3S)-3-(Boc-aMino)-2-Methyl-3-phenylpropionic acid

Chemical Property of (2S,3S)-3-(Boc-aMino)-2-Methyl-3-phenylpropionic acid

Chemical Property:

• PSA: 79.12000
• LogP: 3.17750
• Storage Temp.: 2-8°C

Purity/Quality:

(2S,3S)-3-(Boc-amino)-2-methyl-3-phenylpropionic acid ≥90.0% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S,3S)-3-(Boc-aMino)-2-Methyl-3-phenylpropionic acid

There total 2 articles about (2S,3S)-3-(Boc-aMino)-2-Methyl-3-phenylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

((1S,2S)-2-methyl-3-oxo-1-phenylpropyl)carbamic acid tert-butyl ester (926308-17-0) → C15H21NO4 (926308-22-7,1217456-02-4)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene;

DOI:10.1002/anie.200603188

Reference yield:

tert-butyl benzylidenecarbamate (177896-09-2) → C15H21NO4 (926308-22-7,1217456-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / (S)-proline / dimethylformamide / 16 h / 4 °C

2: 68 percent / NaClO₂; iso-butene; KH₂PO₄ / CHCl₃; 2-methyl-propan-2-ol; H₂O / 16 h / 20 °C

With sodium chlorite; potassium dihydrogenphosphate; L-proline; In chloroform; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.tetlet.2006.11.076

Reference yield: 99.0%

C15H21NO4 (926308-22-7,1217456-02-4) → (2S,3S)-2-methyl-3-phenyl-3-aminopropionic acid hydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

DOI:10.1016/j.tetlet.2006.11.076

upstream raw materials:

((1S,2S)-2-methyl-3-oxo-1-phenylpropyl)carbamic acid tert-butyl ester

tert-butyl benzylidenecarbamate

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