(4-AMINO-FURAZAN-3-YL)-PIPERIDIN-1-YL-METHANONE

Base Information

• Chemical Name: (4-AMINO-FURAZAN-3-YL)-PIPERIDIN-1-YL-METHANONE
• CAS No.: 329922-46-5
• Molecular Formula: C8H12N4O2
• Molecular Weight: 196.21
• Hs Code.: 2934999090
• Mol file: 329922-46-5.mol

Synonyms:TIMTEC-BB SBB000353;(4-AMINO-1,2,5-OXADIAZOL-3-YL)(PIPERIDINO)METHANONE;(4-AMINO-FURAZAN-3-YL)-PIPERIDIN-1-YL-METHANONE;4-(1-Piperidinylcarbonyl)-1,2,5-oxadiazol-3-ylamine

Chemical Property of (4-AMINO-FURAZAN-3-YL)-PIPERIDIN-1-YL-METHANONE

Chemical Property:

• Boiling Point: 403.2±55.0 °C(Predicted)
• PKA: -0.11±0.47(Predicted)
• PSA: 85.25000
• Density: 1.343±0.06 g/cm3(Predicted)
• LogP: 0.79700

Purity/Quality:

98%min ^*data from raw suppliers

4-(piperidin-1-ylcarbonyl)-1,2,5-oxadiazol-3-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-AMINO-FURAZAN-3-YL)-PIPERIDIN-1-YL-METHANONE

There total 3 articles about (4-AMINO-FURAZAN-3-YL)-PIPERIDIN-1-YL-METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C8H14N4O3 → (4-amino-1,2,5-oxadiazol-3-yl)(piperidin-1-yl)methanone (329922-46-5)

Guidance literature:

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; water; at 20 ℃; for 0.0333333h;

DOI:10.1021/acs.orglett.8b00568

Reference yield:

(E)-N-hydroxy-2-oxo-2-(piperidin-1-yl)acetimidoyl cyanide (727987-29-3) → (4-amino-1,2,5-oxadiazol-3-yl)(piperidin-1-yl)methanone (329922-46-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine / water; tetrahydrofuran / 35 °C

2: 1,1'-carbonyldiimidazole / water; tetrahydrofuran / 0.03 h / 20 °C

With hydroxylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; water;

DOI:10.1021/acs.orglett.8b00568

Reference yield:

1-cyanoacetylpiperidine (15029-30-8) → (4-amino-1,2,5-oxadiazol-3-yl)(piperidin-1-yl)methanone (329922-46-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; sodium nitrite / acetonitrile; water / 20 °C

2: hydroxylamine / water; tetrahydrofuran / 35 °C

3: 1,1'-carbonyldiimidazole / water; tetrahydrofuran / 0.03 h / 20 °C

With hydrogenchloride; hydroxylamine; 1,1'-carbonyldiimidazole; sodium nitrite; In tetrahydrofuran; water; acetonitrile;

DOI:10.1021/acs.orglett.8b00568

upstream raw materials:

(E)-N-hydroxy-2-oxo-2-(piperidin-1-yl)acetimidoyl cyanide

1-cyanoacetylpiperidine