(4R)-4-Propyl-L-proline

Base Information

Chemical Name:(4R)-4-Propyl-L-proline
CAS No.:31101-27-6
Molecular Formula:C₈H₁₅NO₂
Molecular Weight:157.213
Hs Code.:
DSSTox Substance ID:DTXSID80558776
Nikkaji Number:J2.833.224F
Mol file:31101-27-6.mol

Synonyms:(4R)-4-Propyl-L-proline;31101-27-6;(2S,4R)-4-propylpyrrolidine-2-carboxylic acid;trans-4-n-propyl-l-proline;SCHEMBL11650754;DTXSID80558776;AKOS015951445

Suppliers and Price of (4R)-4-Propyl-L-proline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of (4R)-4-Propyl-L-proline

Chemical Property:

Melting Point:232 - 234 °C (acetone)
Boiling Point:279.1±33.0 °C(Predicted)
PKA:2.36±0.40(Predicted)
PSA：49.33000
Density:1.040±0.06 g/cm3(Predicted)
LogP:1.17800
XLogP3:-1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:157.110278721
Heavy Atom Count:11
Complexity:147

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC1CC(NC1)C(=O)O
Isomeric SMILES:CCC[C@@H]1C[C@H](NC1)C(=O)O

Technology Process of (4R)-4-Propyl-L-proline

There total 8 articles about (4R)-4-Propyl-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 119595-88-9
(2S,4R)-4-propyl-N-(9-(9-phenylfluorenyl))proline tert-butyl ester

: 31101-27-6
trans-4-propyl-L-pyrrolidine-2-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 16h;
DOI:10.1021/jo00269a022

Reference yield:

: 6734-44-7,13626-47-6,13626-48-7,15385-24-7,31101-27-6
4ξ-n-Propyl-L-prolin

Guidance literature:: 4-Propyliden-1-carbobenzoxy-L-prolin-dicyclohexylaminsalz, 1)KOH-Lsg., Ae., ->4-Propyliden-1-carbobezoxy-L-prolin, 2)Me., Pt/Pd-C, Hydrierung;
DOI:10.1021/ja00986a038

Reference yield:

: 1499-55-4
L-glutamic acid 5-methyl ester

: 31101-27-6
trans-4-propyl-L-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: CHCl₃ / 2 h / Heating

2: lead nitrate, Et₃N / CHCl₃ / 87 h / Ambient temperature

3: 75 percent / CH₂Cl₂ / 16 h / Ambient temperature

4: 1.) potassium hexamethyldisilazide (KHMDS) / 1.) THF, toluene, -78 deg C, 1 h, 2.) THF, toluene, 3 h

5: 56 percent / LiAlH₄ / tetrahydrofuran / 4 h / -20 °C

6: 89 percent / PPh₃, CBr₄, iPr₂NEt / tetrahydrofuran / 1 h / Ambient temperature

7: 90 percent / CF₃CO₂H / CH₂Cl₂ / 16 h

With lithium aluminium tetrahydride; lead(II) nitrate; carbon tetrabromide; potassium hexamethylsilazane; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jo00269a022