(1S)-5,5',6,6',7,7',8,8'-octahydro-3,3'-bis[2,4,6-tris(1-Methylethyl)phenyl]-[1,1'-Binaphthalene]-2,2'-diol

Base Information

Chemical Name:(1S)-5,5',6,6',7,7',8,8'-octahydro-3,3'-bis[2,4,6-tris(1-Methylethyl)phenyl]-[1,1'-Binaphthalene]-2,2'-diol
CAS No.:1197214-47-3
Molecular Formula:C50H66O2
Molecular Weight:699.05784
Hs Code.:
Mol file:1197214-47-3.mol

Synonyms:(1S)-5,5',6,6',7,7',8,8'-octahydro-3,3'-bis[2,4,6-tris(1-Methylethyl)phenyl]-[1,1'-Binaphthalene]-2,2'-diol

Suppliers and Price of (1S)-5,5',6,6',7,7',8,8'-octahydro-3,3'-bis[2,4,6-tris(1-Methylethyl)phenyl]-[1,1'-Binaphthalene]-2,2'-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 4 raw suppliers

Chemical Property of (1S)-5,5',6,6',7,7',8,8'-octahydro-3,3'-bis[2,4,6-tris(1-Methylethyl)phenyl]-[1,1'-Binaphthalene]-2,2'-diol

Chemical Property:

Boiling Point:735.8±60.0 °C(Predicted)
PKA:9.27±0.20(Predicted)
PSA：40.46000
Density:1.033±0.06 g/cm3(Predicted)
LogP:14.59680

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S)-5,5',6,6',7,7',8,8'-octahydro-3,3'-bis[2,4,6-tris(1-Methylethyl)phenyl]-[1,1'-Binaphthalene]-2,2'-diol

There total 10 articles about (1S)-5,5',6,6',7,7',8,8'-octahydro-3,3'-bis[2,4,6-tris(1-Methylethyl)phenyl]-[1,1'-Binaphthalene]-2,2'-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: (3r,3's)-2,2'-bis(methoxymethoxy)-3,3'-bis(2,4,6-triisopropylphenyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'binaphthalene

: 1197214-47-3
(R_a)-3,3’-bis(2,4,6-triisopropylphenyl)-5,5’,6,6’,7,7’,8,8’-octahydro-[1,1’-binaphthalene]-2,2’-diol

Guidance literature:: With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/anie.201303527

Reference yield: 88.0%

: (Ra)-2,2’-dimethoxy-3,3’-bis(2,4,6-triisopropylphenyl)-5,5’,6,6’,7,7’,8,8’-octahydro-1,1’-binaphthalene

: 1197214-47-3
(R_a)-3,3’-bis(2,4,6-triisopropylphenyl)-5,5’,6,6’,7,7’,8,8’-octahydro-[1,1’-binaphthalene]-2,2’-diol

Guidance literature:: With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/chem.201406133

Reference yield:

: 39648-74-3,65355-00-2,65355-14-8
(Ra)-5,6,7,8,5',6',7',8'-octahydro-[1,1']binaphthalenyl-2,2'-diol

: 1197214-47-3
(R_a)-3,3’-bis(2,4,6-triisopropylphenyl)-5,5’,6,6’,7,7’,8,8’-octahydro-[1,1’-binaphthalene]-2,2’-diol

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / dichloromethane / 2 h / -40 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 - 20 °C / Inert atmosphere

2.2: 3 h / 0 - 20 °C / Inert atmosphere

3.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 - 20 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: bis(triphenylphosphine)nickel(II) chloride / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere; Reflux

5.1: boron tribromide / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

With bis(triphenylphosphine)nickel(II) chloride; n-butyllithium; bromine; boron tribromide; sodium hydride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; mineral oil; 4.1: |Kumada Cross-Coupling;
DOI:10.1002/anie.201303527