tert-butyl 2-(5-bromopyridin-2-yl)-2-oxoethylcarbamate

Base Information

Chemical Name:tert-butyl 2-(5-bromopyridin-2-yl)-2-oxoethylcarbamate
CAS No.:950176-70-2
Molecular Formula:C12H15BrN2O3
Molecular Weight:315.16
Hs Code.:
Mol file:950176-70-2.mol

Synonyms:tert-butyl 2-(5-bromopyridin-2-yl)-2-oxoethylcarbamate;[2-(5-Bromo-pyridin-2-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Suppliers and Price of tert-butyl 2-(5-bromopyridin-2-yl)-2-oxoethylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl(2-(5-bromopyridin-2-yl)-2-oxoethyl)carbamate 97%
5g
$ 880.00

Alichem
tert-Butyl(2-(5-bromopyridin-2-yl)-2-oxoethyl)carbamate
1g
$ 860.00

Aaron Chemicals
TERT-BUTYL(2-(5-BROMOPYRIDIN-2-YL)-2-OXOETHYL)CARBAMATE 95%
10g
$ 500.00

Aaron Chemicals
TERT-BUTYL(2-(5-BROMOPYRIDIN-2-YL)-2-OXOETHYL)CARBAMATE 95%
5g
$ 281.00

Total 2 raw suppliers

Chemical Property of tert-butyl 2-(5-bromopyridin-2-yl)-2-oxoethylcarbamate

Chemical Property:

PSA：68.29000
LogP:2.94240

Purity/Quality:

98% ^*data from raw suppliers

tert-Butyl(2-(5-bromopyridin-2-yl)-2-oxoethyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(5-bromopyridin-2-yl)-2-oxoethylcarbamate

There total 2 articles about tert-butyl 2-(5-bromopyridin-2-yl)-2-oxoethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 624-28-2
2,5-dibromopyridine

: 121505-93-9
tert-butyl N-{[methoxy(methyl)carbamoyl]methyl}carbamate

: 950176-70-2
tert-butyl (2-(5-bromopyridin-2-yl)-2-oxoethyl)carbamate

Guidance literature:: 2,5-dibromopyridine; With n-butyllithium; In hexane; toluene; at -78 ℃; for 2.5h;

tert-butyl N-{[methoxy(methyl)carbamoyl]methyl}carbamate; In hexane; toluene; at -78 - -15 ℃; for 4h;
DOI:10.1021/jm401836p

Reference yield:

: 121505-93-9
tert-butyl N-{[methoxy(methyl)carbamoyl]methyl}carbamate

: 950176-70-2
tert-butyl (2-(5-bromopyridin-2-yl)-2-oxoethyl)carbamate

Guidance literature:: 2,5-dibromopyridine; With n-butyllithium; In hexanes; toluene; at -78 ℃; for 2.75h;

tert-butyl N-{[methoxy(methyl)carbamoyl]methyl}carbamate; In hexane; toluene; at -78 - -15 ℃; for 4.11667h;

Reference yield:

: 950176-70-2
tert-butyl (2-(5-bromopyridin-2-yl)-2-oxoethyl)carbamate

: 1007883-14-8
C₂₅H₂₇N₇

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen bromide / 1,4-dioxane / 17.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

3.1: ammonium acetate / 5,5-dimethyl-1,3-cyclohexadiene / 1.5 h / 140 °C / Microwave irradiation

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

4.2: 14 h / 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,2-dimethoxyethane; water / 24 h / 80 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 10 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; hydrogen bromide; sodium hydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; 1,2-dimethoxyethane; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 5.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm401836p