[6-Morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-yl]hydrazine

Base Information

Chemical Name:[6-Morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-yl]hydrazine
CAS No.:719285-83-3
Molecular Formula:C15H20N6O2
Molecular Weight:316.363
Hs Code.:
European Community (EC) Number:615-696-7
DSSTox Substance ID:DTXSID801165401
ChEMBL ID:CHEMBL1996208
Mol file:719285-83-3.mol

Synonyms:719285-83-3;[6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-yl]hydrazine;4-(6-Hydrazinyl-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine;6-(4-Morpholinyl)-2-[2-(2-pyridinyl)ethoxy]-4(1H)-pyrimidinone Hydrazone;Kinome_3581;SCHEMBL1616481;CHEMBL1996208;DTXSID801165401;AKOS024281833;2-[2-(pyridin-2-yl)-ethoxy]-4-hydrazino-6-(morpholin-4-yl)-pyrimidine;4-[6-Hydrazinyl-2-[2-(2-pyridinyl)ethoxy]-4-pyrimidinyl]morpholine

Suppliers and Price of [6-Morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-yl]hydrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-(4-Morpholinyl)-2-[2-(2-pyridinyl)ethoxy]-4(1H)-pyrimidinoneHydrazone
25mg
$ 165.00

Medical Isotopes, Inc.
6-(4-Morpholinyl)-2-[2-(2-pyridinyl)ethoxy]-4(1H)-pyrimidinoneHydrazone
250 mg
$ 2200.00

Total 4 raw suppliers

Chemical Property of [6-Morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-yl]hydrazine

Chemical Property:

Vapor Pressure:2.97E-14mmHg at 25°C
Boiling Point:597.8°C at 760 mmHg
Flash Point:315.4°C
PSA：98.42000
Density:1.316g/cm³
LogP:1.45360
Solubility.:Dimethylsulfoxide, Ethyl Acetate, Methanol
XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:316.16477390
Heavy Atom Count:23
Complexity:342

Purity/Quality:

95+% ^*data from raw suppliers

6-(4-Morpholinyl)-2-[2-(2-pyridinyl)ethoxy]-4(1H)-pyrimidinoneHydrazone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COCCN1C2=NC(=NC(=C2)NN)OCCC3=CC=CC=N3

Technology Process of [6-Morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-yl]hydrazine

There total 3 articles about [6-Morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-yl]hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 544693-01-8
4-(6-chloro-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine

: 887402-10-0
6-[2-(pyridin-2-yl)-ethoxy]-2-chloro-4-(morpholin-4-yl)-pyrimidine

: 887402-09-7
4-[2-(pyridin-2-yl)-ethoxy]-6-chloro-2-(morpholin-4-yl)-pyrimidine

: 719285-83-3
4-(6-hydrazinyl-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine

Guidance literature:: With hydrazine; In 1,4-dioxane; for 5h; Heating / reflux;

Reference yield: 71.0%

: 544693-01-8
4-(6-chloro-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine

: 719285-83-3
4-(6-hydrazinyl-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine

Guidance literature:: With hydrazine hydrate; In 1,4-dioxane; at 95 ℃;

Reference yield:

: 52127-83-0
4-(2,6-dichloropyrimidin-4-yl)morpholine

: 719285-83-3
4-(6-hydrazinyl-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 0.75 h / -20 - 0 °C

2.1: hydrazine hydrate / 1,4-dioxane / 95 °C

With sodium hydride; hydrazine hydrate; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;