5-(2-Pyridyl)isoxazole-3-carboxylic Acid

Base Information

• Chemical Name: 5-(2-Pyridyl)isoxazole-3-carboxylic Acid
• CAS No.: 893638-37-4
• Molecular Formula: C₉H₆N₂O₃
• Molecular Weight: 190.158
• Hs Code.: 2934999090
• Mol file: 893638-37-4.mol

Synonyms:5-(2-Pyridyl)isoxazole-3-carboxylic Acid;5-(Pyridin-2-yl)isoxazole-3-carboxylic acid;5-(2-pyridinyl)-3-Isoxazolecarboxylic acid

Chemical Property of 5-(2-Pyridyl)isoxazole-3-carboxylic Acid

Chemical Property:

• PSA: 76.22000
• LogP: 1.43480
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

5-(2-Pyridyl)isoxazole-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-(2-Pyridyl)isoxazole-3-carboxylic Acid is a useful reagent for the preparation of isoxazoles for treatment of neurological disease.

Technology Process of 5-(2-Pyridyl)isoxazole-3-carboxylic Acid

There total 3 articles about 5-(2-Pyridyl)isoxazole-3-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

ethyl 5-(pyridin-2-yl)isoxazole-3-carboxylate (893638-49-8) → 5-(pyridin-2-yl)-1,2-oxazole-3-carboxylic acid (893638-37-4)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; for 16h;

Reference yield:

ethyl 2,4-dioxo-4-(pyridin-2-yl)butanoate (92288-93-2) → 5-(pyridin-2-yl)-1,2-oxazole-3-carboxylic acid (893638-37-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride / ethanol / 48 h / 85 °C

2: lithium hydroxide; water / tetrahydrofuran; methanol / 16 h

With hydroxylamine hydrochloride; water; lithium hydroxide; In tetrahydrofuran; methanol; ethanol;

Reference yield:

2-acetylpyridine (1122-62-9) → 5-(pyridin-2-yl)-1,2-oxazole-3-carboxylic acid (893638-37-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 20 °C

1.2: 18 h / 0 - 20 °C

2.1: hydroxylamine hydrochloride / ethanol / 48 h / 85 °C

3.1: lithium hydroxide; water / tetrahydrofuran; methanol / 16 h

With hydroxylamine hydrochloride; water; sodium hydride; lithium hydroxide; In tetrahydrofuran; methanol; ethanol;

upstream raw materials:

ethyl 2,4-dioxo-4-(pyridin-2-yl)butanoate

ethyl 5-(pyridin-2-yl)isoxazole-3-carboxylate

2-acetylpyridine

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