3-BroMoisonicotinoyl chloride

Base Information

• Chemical Name: 3-BroMoisonicotinoyl chloride
• CAS No.: 71541-33-8
• Molecular Formula: C6H3BrClNO
• Molecular Weight: 220.46
• Mol file: 71541-33-8.mol

Synonyms:3-BroMoisonicotinoyl chloride;3-Bromopyridine-4-carbonyl chloride

Chemical Property of 3-BroMoisonicotinoyl chloride

Chemical Property:

• PSA: 29.96000
• LogP: 2.22310

Purity/Quality:

95% ^*data from raw suppliers

3-Bromopyridine-4-carbonylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BroMoisonicotinoyl chloride

There total 1 articles about 3-BroMoisonicotinoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromoisonicotinic acid (13959-02-9) → 3-Bromoisonicotinoyl chloride (71541-33-8)

Guidance literature:

With thionyl chloride; for 3h; Heating;

DOI:10.1021/jm0210461

Reference yield:

3-Bromoisonicotinoyl chloride (71541-33-8) + benzylamine (100-46-9) → N-benzyl-3-bromopyridine-4-carboxamide (1203396-67-1)

Guidance literature:

With triethylamine; In dichloromethane; for 1h; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.08.070

Reference yield:

3-Bromoisonicotinoyl chloride (71541-33-8) + 2-phenyl-2-propylamine (585-32-0) → 3-bromo-N-(2-phenyl-2-propyl)isonicotinamide (1240662-87-6)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja104297g

upstream raw materials:

3-bromoisonicotinic acid

Downstream raw materials:

1-(3-bromopyridin-4-yl)ethan-1-one

{2-[4-(3-methyl-butylcarbamoyl)-pyridin-3-yl]-benzyl}-carbamic acid tert-butyl ester

3-bromo-N-methyl-N-(methyloxy)-4-pyridinecarboxamide

3-bromo-N-(2-phenyl-2-propyl)isonicotinamide

Refernces

• 1、 Wei, Dong,Hu, Tian-Jiao,Feng, Chen-Guo,Lin, Guo-Qiang. "Synthesis of Substituted Naphthalenes by 1,4-Palladium Migration Involved Annulation with Internal Alkynes". supporting information. p. 743 - 748. Retrieved 2018/07/25.
• 2、 Shen, Xiaoqiang,Jones, Gavin O.,Watson, Donald A.,Bhayana, Brijesh,Buchwald, Stephen L.. "Enantioselective synthesis of axially chiral biaryls by the pd-catalyzed suzuki-miyaura reaction: Substrate scope and quantum mechanical investigations". supporting information; experimental part. p. 11278 - 11287. Retrieved 2010/10/04.