Technology Process of Vps34-IN-1
There total 6 articles about Vps34-IN-1 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-Amino-2-chloropyridine;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 0.5h;
Inert atmosphere;
1-(4'-(cyclopropylmethyl)-2-(methylsulfinyl)-4,5'-bipyrimidin-2'-ylamino)-2-methylpropan-2-ol;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -10 - 20 °C / Inert atmosphere
1.2: 2 h / 20 °C
2.1: tetrahydrofuran / 2 h / 80 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 120 °C
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C
5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - 20 °C / Inert atmosphere
5.2: 1 h / 20 °C
With
potassium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -10 - 20 °C / Inert atmosphere
1.2: 2 h / 20 °C
2.1: tetrahydrofuran / 2 h / 80 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 120 °C
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C
5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - 20 °C / Inert atmosphere
5.2: 1 h / 20 °C
With
potassium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
