6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

Base Information

• Chemical Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
• CAS No.: 1139889-93-2
• Molecular Formula: C₁₇H₁₄F₂N₂
• Molecular Weight: 284.308
• Mol file: 1139889-93-2.mol

Synonyms:6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline;Golgicide A;3H-Cyclopenta[c]quinoline, 6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-, (3aR,9bS)-rel-

Chemical Property of 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

Chemical Property:

• PSA: 24.92000
• LogP: 4.32430
• Storage Temp.: Store at RT
• Solubility.: insoluble in H2O; ≥12.95 mg/mL in DMSO; ≥2.27 mg/mL in EtOH with ultrasonic

Purity/Quality:

99%+, ^*data from raw suppliers

Golgicide A ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Golgicide A, Golgicide A, a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1.

Technology Process of 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

There total 1 articles about 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-pyridinecarboxaldehyde (500-22-1) + 2,4-difluorophenylamine (367-25-9,76563-56-9) + cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) → GCA (1139889-93-2) + C17H14F2N2

Guidance literature:

With oxalic acid; In acetonitrile; at 90 ℃; for 8h; optical yield given as %de; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.06.076

Reference yield:

GCA (1139889-93-2) → C17H14F2N2 (1394285-50-7) + C17H14F2N2 (1394285-49-4)

Guidance literature:

With Chiralpac IB column; In hexane; isopropyl alcohol; Resolution of racemate;

DOI:10.1016/j.bmcl.2012.06.076

upstream raw materials:

3-pyridinecarboxaldehyde

2,4-difluorophenylamine

cyclopenta-1,3-diene

Downstream raw materials:

C₁₇H₁₄F₂N₂

C₁₇H₁₄F₂N₂

Refernces