siMeprevir interMediate

Base Information

Chemical Name:siMeprevir interMediate
CAS No.:923604-57-3
Molecular Formula:C₃₇H₄₆N₄O₆S
Molecular Weight:674.861
Hs Code.:
Mol file:923604-57-3.mol

Synonyms:siMeprevir interMediate;(2R,3aR,10Z,11aS,12aR,14aR)-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-Tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxylic acid ethyl ester;Simeprevir cyclized intermediate

Suppliers and Price of siMeprevir interMediate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 7 raw suppliers

Chemical Property of siMeprevir interMediate

Chemical Property:

Vapor Pressure:0-0Pa at 20-25℃
PKA:13.24±0.60(Predicted)
PSA：148.19000
Density:1 +-.0.06 g/cm3(Predicted)
LogP:6.72150

Purity/Quality:: 99.9% ^*data from raw suppliers

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Technology Process of siMeprevir interMediate

There total 17 articles about siMeprevir interMediate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 13-tert-butyl 12a-ethyl (2S,3aR,10Z,11aS,12aR,14aR)-2-({7-methoxy-8-methyl-2-[4-(propan-2-yl)-1,3-thiazol-2-yl]-quinolin-4-yl}oxy)-5-methyl-4,14-dioxo-1,2,3,3a,4,5,6,7,8,9,11a,12,14,14a-tetradecahydrocyclopenta[c]cyclopropa[g]-[1,6]diazacyclotetradecine-12a,13-dicarboxylate

: 923604-57-3
2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-10(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-(2R,3aR,10Z,11aS,2aR,14aR)-cyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxylic acid ethyl ester

Guidance literature:: With sulfuric acid; at 80 ℃; for 6h; Reagent/catalyst;
DOI:10.1021/acs.joc.8b03124

Reference yield: 64.0%

: 1431935-29-3
C₃₉H₄₅F₃N₄O₇S

: 923604-57-3
2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-10(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-(2R,3aR,10Z,11aS,2aR,14aR)-cyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxylic acid ethyl ester

Guidance literature:: C₃₉H₄₅F₃N₄O₇S; With 3-carboxy-2-mercaptopyridine; triethylamine; In dichloromethane; butan-1-ol; at 30 ℃;

With dimethyl amine; In dichloromethane; water; for 2h;