(R)-(+)-5'-HYDROXYPHENYL-CARVEDILOL

Base Information

Chemical Name:(R)-(+)-5'-HYDROXYPHENYL-CARVEDILOL
CAS No.:1217757-71-5
Molecular Formula:C24H26N2O5
Molecular Weight:422.47
Hs Code.:
Mol file:1217757-71-5.mol

Synonyms:(R)-(+)-5'-HYDROXYPHENYL-CARVEDILOL;(R)-(+)-M4;(R)-(+)-BM 140830;(R)-3-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-4-methoxyphenol;(R)-5-Hydroxycarvedilol

Suppliers and Price of (R)-(+)-5'-HYDROXYPHENYL-CARVEDILOL

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-(+)-5’-HydroxyphenylCarvedilol
10mg
$ 1190.00

Total 8 raw suppliers

Chemical Property of (R)-(+)-5'-HYDROXYPHENYL-CARVEDILOL

Chemical Property:

Melting Point:205-207°C
Boiling Point:702.0±60.0 °C(Predicted)
PKA:10.06±0.18(Predicted)
PSA：95.97000
Density:1.305±0.06 g/cm3(Predicted)
LogP:3.83450
Storage Temp.:-20°C Freezer

Purity/Quality:

99% ^*data from raw suppliers

(R)-(+)-5’-HydroxyphenylCarvedilol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (R)-(+)-5'-HYDROXYPHENYL-CARVEDILOL is an optically active metabolite of Carvedilol which is a multiple-action, neurohormonal antagonist that is used in the treatment of hypertension. An optically active metabolite of Carvedilol (C184625), a nonselective ?-adrenergic blocker with α1-blocking activity.

Technology Process of (R)-(+)-5'-HYDROXYPHENYL-CARVEDILOL

There total 8 articles about (R)-(+)-5'-HYDROXYPHENYL-CARVEDILOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1076198-81-6
C₉H₁₃NO₃

: 51997-51-4,95093-96-2
4-(2,3-epoxypropoxy)carbazole

: 1217757-71-5,142227-51-8
5'-Hydroxyphenyl carvedilol

Guidance literature:: With lithium bromide; In isopropyl alcohol; for 12h; Reflux;
DOI:10.1016/j.bmcl.2015.11.008

Reference yield:

: 1262778-73-3
4-methoxy-3-(2-phthalimidoethoxy)phenol

: 1217757-71-5,142227-51-8
5'-Hydroxyphenyl carvedilol

Guidance literature:: Multi-step reaction with 2 steps

1.1: methylamine / methanol / 30 °C

1.2: 30 °C

2.1: triethylamine / isopropyl alcohol / 45 °C

With triethylamine; methylamine; In methanol; isopropyl alcohol;
DOI:10.1080/00397910903534072