(1-{2-[6-(4-{2-[1-(2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-ylethynyl}phenyl)-1H-benzoimidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Base Information

Chemical Name:(1-{2-[6-(4-{2-[1-(2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-ylethynyl}phenyl)-1H-benzoimidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester
CAS No.:1228968-06-6
Molecular Formula:C₄₀H₄₈N₈O₆
Molecular Weight:736.871
Hs Code.:
Mol file:1228968-06-6.mol

(1-{2-[6-(4-{2-[1-(2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-ylethynyl}phenyl)-1H-benzoimidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Synonyms:(1-{2-[6-(4-{2-[1-(2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-ylethynyl}phenyl)-1H-benzoimidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

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Chemical Property of (1-{2-[6-(4-{2-[1-(2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-ylethynyl}phenyl)-1H-benzoimidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

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Technology Process of (1-{2-[6-(4-{2-[1-(2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-ylethynyl}phenyl)-1H-benzoimidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

There total 18 articles about (1-{2-[6-(4-{2-[1-(2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3H-imidazol-4-ylethynyl}phenyl)-1H-benzoimidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1228969-00-3
{1-[2-(5-ethynyl-1H-imidazol-2-yl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}carbamic acid methyl ester

: 1256387-59-3
(S)-2-(acetoxyamino)-1-((S)-2-(6-(4-bromophenyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-1-yl)-3-methylbutan-1-one

: 1228968-06-6
(1-{2-[6-(4-{2-[1-(2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3Himidazol-4-ylethynyl}phenyl)-1H-benzoimidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 3h;
DOI:10.1021/jm401499g

Reference yield:

: C₃₃H₃₇N₇O₃*(x)ClH

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1228968-06-6
(1-{2-[6-(4-{2-[1-(2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3Himidazol-4-ylethynyl}phenyl)-1H-benzoimidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

Reference yield:

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1228968-06-6
(1-{2-[6-(4-{2-[1-(2-methoxycarbonylamino-3-methylbutyryl)pyrrolidin-2-yl]-3Himidazol-4-ylethynyl}phenyl)-1H-benzoimidazol-2-yl]pyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 1 h / 80 °C / Microwave irradiation

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 4 h / 95 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 16 h / 85 °C / Inert atmosphere

4.1: hydrogenchloride / methanol; water / 3 h / 50 °C

4.2: 13 h / 0 °C

5.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 3 h / 80 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; 2.1: |Miyaura Borylation Reaction / 3.1: |Suzuki Coupling / 5.1: |Sonogashira Cross-Coupling;
DOI:10.1021/jm401499g