FLAVONE, 6-FLUORO-3-HYDROXY-3',4'-(METHYLENEDIOXY)-

Base Information

• Chemical Name: FLAVONE, 6-FLUORO-3-HYDROXY-3',4'-(METHYLENEDIOXY)-
• CAS No.: 4257-54-9
• Molecular Formula: C₁₆H₉FO₅
• Molecular Weight: 300.243
• Mol file: 4257-54-9.mol

Synonyms:FLAVONE, 6-FLUORO-3-HYDROXY-3',4'-(METHYLENEDIOXY)-

Chemical Property of FLAVONE, 6-FLUORO-3-HYDROXY-3',4'-(METHYLENEDIOXY)-

Chemical Property:

• Vapor Pressure: 2.44E-09mmHg at 25°C
• Melting Point: 116 °C
• Boiling Point: 462.2°C at 760 mmHg
• PKA: 8.20±0.20(Predicted)
• Flash Point: 233.3°C
• PSA: 68.90000
• Density: 1.583g/cm³
• LogP: 3.03340

Purity/Quality:

6-FLUORO-3-HYDROXY-3',4'-(METHYLENEDIOXY)-FLAVONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FLAVONE, 6-FLUORO-3-HYDROXY-3',4'-(METHYLENEDIOXY)-

There total 3 articles about FLAVONE, 6-FLUORO-3-HYDROXY-3',4'-(METHYLENEDIOXY)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

3-(Benzo[1,3]dioxol-5-yl)-1-(5-fluoro-2-hydroxyphenyl)-2-propen-1-one → 2-(benzo[d][1,3]dioxol-5-yl)-6-fluoro-3-hydroxy-4H-chromen-4-one (4257-54-9)

Guidance literature:

With dihydrogen peroxide; sodium hydroxide; In ethanol; at 20 ℃; Cooling with ice;

DOI:10.1021/acsmedchemlett.8b00565

Reference yield:

piperonal (120-57-0,30024-74-9) + 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one (394-32-1) → 2-(benzo[d][1,3]dioxol-5-yl)-6-fluoro-3-hydroxy-4H-chromen-4-one (4257-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 20 °C

2: sodium hydroxide; dihydrogen peroxide / ethanol / 20 °C / Cooling with ice

With dihydrogen peroxide; sodium hydroxide; In ethanol; 1: |Claisen-Schmidt Condensation;

DOI:10.1021/acsmedchemlett.8b00565

Reference yield:

→ 2-(benzo[d][1,3]dioxol-5-yl)-6-fluoro-3-hydroxy-4H-chromen-4-one (4257-54-9)

Guidance literature:

5'-Fluor-2'-hydroxy-3,4-methylendioxychalkon, 1) NaOH in Me., 2) Oxidation mit 18percent H2O2;

upstream raw materials:

piperonal

1-(5-fluoro-2-hydroxyphenyl)ethan-1-one

Refernces