Technology Process of Dabigatran Etexilate N-Oxide
There total 10 articles about Dabigatran Etexilate N-Oxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dihydrogen peroxide;
In
methanol;
at 25 - 30 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 50 - 55 °C
1.2: 50 h / 50 - 65 °C
2.1: calcium(II) chloride dihydrate / ethanol / 0.33 h
2.2: 13 h / 0 - 30 °C
2.3: 10.5 h / 0 - 35 °C
3.1: potassium carbonate / acetonitrile; water / 0.25 h / 12 - 18 °C
3.2: 14.42 h / 12 - 20 °C
4.1: dihydrogen peroxide / methanol / 24 h / 25 - 30 °C
With
calcium(II) chloride dihydrate; dihydrogen peroxide; potassium carbonate; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; methanol; ethanol; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium iodide; sodium hydrogencarbonate; tetrabutylammomium bromide / water / 24 h / 90 - 95 °C
1.2: 0.33 h / 20 - 30 °C / pH 7.5
1.3: 3 h / 20 - 30 °C / pH 2.5
2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 50 - 55 °C
2.2: 50 h / 50 - 65 °C
3.1: calcium(II) chloride dihydrate / ethanol / 0.33 h
3.2: 13 h / 0 - 30 °C
3.3: 10.5 h / 0 - 35 °C
4.1: potassium carbonate / acetonitrile; water / 0.25 h / 12 - 18 °C
4.2: 14.42 h / 12 - 20 °C
5.1: dihydrogen peroxide / methanol / 24 h / 25 - 30 °C
With
calcium(II) chloride dihydrate; tetrabutylammomium bromide; dihydrogen peroxide; sodium hydrogencarbonate; potassium carbonate; 1,1'-carbonyldiimidazole; potassium iodide;
In
tetrahydrofuran; methanol; ethanol; water; acetonitrile;
