1-Hydroxy-2,2,6,6-tetramethyl-4-piperidinone

Base Information

• Chemical Name: 1-Hydroxy-2,2,6,6-tetramethyl-4-piperidinone
• CAS No.: 3637-11-4
• Molecular Formula: C9H17NO2
• Molecular Weight: 171.239
• Hs Code.: 2933399090
• NSC Number: 156571
• DSSTox Substance ID: DTXSID30189892
• Nikkaji Number: J793.733D
• Wikidata: Q27268928,Q83062119
• ChEMBL ID: CHEMBL326931
• Mol file: 3637-11-4.mol

Synonyms:1-hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine;1-hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine hydrochloride;TEMPONE-H

Chemical Property of 1-Hydroxy-2,2,6,6-tetramethyl-4-piperidinone

Chemical Property:

• Boiling Point: 257.5°Cat760mmHg
• Flash Point: 109.5°C
• PSA: 40.54000
• Density: 1.02g/cm³
• LogP: 1.53560
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 171.125928785
• Heavy Atom Count: 12
• Complexity: 189

Purity/Quality:

97% ^*data from raw suppliers

1-Hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CC(=O)CC(N1O)(C)C)C
• Uses: 1-Hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine Hydrochloride is a very effective, cell permeable and non-toxic spin trap for the detection of superoxide radical and peroxynitrite.

Technology Process of 1-Hydroxy-2,2,6,6-tetramethyl-4-piperidinone

There total 19 articles about 1-Hydroxy-2,2,6,6-tetramethyl-4-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2,2,6,6-Tetramethyl-4-piperidone (826-36-8) → 1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-one (3637-11-4) + 4-oxo-2,2,6,6-tetramethylpiperidin-oxyl (45985-26-0,2896-70-0) + 2,6-dimethyl-2-nitrosohept-5-en-4-one (22963-72-0) + 2,6-dimethyl-2-nitrohept-5-en-4-one (57699-34-0)

Guidance literature:

With sodium tungstate; dihydrogen peroxide; disodium ethylenediaminetetraacetic acid; In water;

Reference yield: 43.0%

2,2,6,6-Tetramethyl-4-piperidone (826-36-8) → 1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-one (3637-11-4) + 4-oxo-2,2,6,6-tetramethylpiperidin-oxyl (45985-26-0,2896-70-0) + 2,6-dimethyl-2-nitrosohept-5-en-4-one (22963-72-0) + 2,6-dimethyl-6-nitroso-hept-1-en-4-one (66737-13-1)

Guidance literature:

With sodium tungstate; dihydrogen peroxide; disodium ethylenediaminetetraacetic acid; In water;

Reference yield: 43.0%

2,2,6,6-Tetramethyl-4-piperidone (826-36-8) → 1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-one (3637-11-4) + 4-oxo-2,2,6,6-tetramethylpiperidin-oxyl (45985-26-0,2896-70-0) + 2,6-dimethyl-2-nitrosohept-5-en-4-one (22963-72-0) + 2,6-dimethyl-6-nitroso-hept-1-en-4-one (66737-13-1) + 2,6-dimethyl-2-nitrohept-5-en-4-one (57699-34-0)

Guidance literature:

With sodium tungstate; dihydrogen peroxide; disodium ethylenediaminetetraacetic acid; In water; Product distribution;

upstream raw materials:

2,2,6,6-Tetramethyl-4-piperidone

4-oxo-2,2,6,6-tetramethylpiperidin-oxyl

N-hydroxy-N-(1,1-dimethylethyl)benzamide

N-(3-Phenylpropanoyl)-N-tert-butylhydroxylamin

Downstream raw materials:

4-oxo-2,2,6,6-tetramethylpiperidin-oxyl

2,4,6-triphenylverdazyl

4,6-Diphenyl-2-p-tolyl-1,2,3,4-tetrahydro-[1,2,4,5]tetrazine

2-(4-Chloro-phenyl)-4,6-diphenyl-1,2,3,4-tetrahydro-[1,2,4,5]tetrazine