Technology Process of 4-Chloro-1-(2-methylphenyl)-1-oxobutane
There total 4 articles about 4-Chloro-1-(2-methylphenyl)-1-oxobutane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,10-Phenanthroline; tert-butylhypochlorite; silver trifluoromethanesulfonate;
In
acetonitrile;
at 20 ℃;
for 6h;
regioselective reaction;
Inert atmosphere;
Schlenk technique;
DOI:10.1021/acs.orglett.5b03649
- Guidance literature:
-
With
trifluorormethanesulfonic acid; water;
In
2,2,2-trifluoroethanol;
at 60 ℃;
for 6h;
regioselective reaction;
Sealed tube;
DOI:10.1021/acs.jmedchem.9b00864
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: iodine; magnesium / tetrahydrofuran / Inert atmosphere; Reflux; Sealed tube
1.2: 0 - 20 °C / Inert atmosphere; Sealed tube
2.1: acetic acid; manganese(II) triflate; magnesium chloride; tetrabutylammonium acetate / acetonitrile / 3.5 h / 25 °C / Inert atmosphere; Electrochemical reaction; Sealed tube
With
manganese(II) triflate; iodine; tetrabutylammonium acetate; magnesium; acetic acid; magnesium chloride;
In
tetrahydrofuran; acetonitrile;
DOI:10.1021/acs.orglett.9b03652
