5,7-Dimethoxyphenanthren-1-ol

Base Information

• Chemical Name: 5,7-Dimethoxyphenanthren-1-ol
• CAS No.: 53077-36-4
• Molecular Formula: C₁₆H₁₄O₃
• Molecular Weight: 254.285
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID00701686
• Nikkaji Number: J89.746I
• Wikidata: Q82633444
• Mol file: 53077-36-4.mol

Synonyms:5,7-Dimethoxyphenanthren-1-ol;53077-36-4;DTXSID00701686

Chemical Property of 5,7-Dimethoxyphenanthren-1-ol

Chemical Property:

• Boiling Point: 474.9±25.0 °C(Predicted)
• PKA: 9.18±0.30(Predicted)
• PSA: 38.69000
• Density: 1.245±0.06 g/cm3(Predicted)
• LogP: 3.71580
• XLogP3: 4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 254.094294304
• Heavy Atom Count: 19
• Complexity: 306

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=C2C(=C1)C=CC3=C2C=CC=C3O)OC

Technology Process of 5,7-Dimethoxyphenanthren-1-ol

There total 5 articles about 5,7-Dimethoxyphenanthren-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,8-dimethoxy-3,4-dihydro-2H-naphthalen-1-one (883-07-8) → 2,4-Dimethoxy-8-hydroxyphenanthren (53077-36-4)

Guidance literature:

Multi-step reaction with 5 steps

1: Zn, HgCl₂, I₂ / benzene

2: Pd-C / 200 °C

3: KOH / aq. ethanol

4: polyphosphoric acid

5: Pd-C / 180 - 200 °C

With potassium hydroxide; PPA; iodine; mercury dichloride; zinc; palladium on activated charcoal; In ethanol; benzene;

DOI:10.1002/hlca.19740570334

Reference yield:

4-(6,8-Dimethoxy-naphthalen-1-yl)-butyric acid methyl ester (53076-49-6) → 2,4-Dimethoxy-8-hydroxyphenanthren (53077-36-4)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH / aq. ethanol

2: polyphosphoric acid

3: Pd-C / 180 - 200 °C

With potassium hydroxide; PPA; palladium on activated charcoal; In ethanol;

DOI:10.1002/hlca.19740570334

Reference yield:

(E)-4-[6,8-Dimethoxy-3,4-dihydro-2H-naphthalen-(1E)-ylidene]-but-2-enoic acid methyl ester (53076-47-4) → 2,4-Dimethoxy-8-hydroxyphenanthren (53077-36-4)

Guidance literature:

Multi-step reaction with 4 steps

1: Pd-C / 200 °C

2: KOH / aq. ethanol

3: polyphosphoric acid

4: Pd-C / 180 - 200 °C

With potassium hydroxide; PPA; palladium on activated charcoal; In ethanol;

DOI:10.1002/hlca.19740570334

upstream raw materials:

5,7-Dimethoxy-3,4-dihydro-2H-phenanthren-1-one

6,8-dimethoxy-3,4-dihydro-2H-naphthalen-1-one

γ-(6,8-Dimethoxy-1-naphthyl)-buttersaeure

4-(6,8-Dimethoxy-naphthalen-1-yl)-butyric acid methyl ester