5-Pyrimidinecarboxylic acid, 2-amino-4-(1,1-dimethylethyl)- (9CI)

Base Information

• Chemical Name: 5-Pyrimidinecarboxylic acid, 2-amino-4-(1,1-dimethylethyl)- (9CI)
• CAS No.: 127958-04-7
• Molecular Formula: C₉H₁₃N₃O₂
• Molecular Weight: 195.221
• Mol file: 127958-04-7.mol

Synonyms:5-Pyrimidinecarboxylic acid, 2-amino-4-(1,1-dimethylethyl)- (9CI)

Chemical Property of 5-Pyrimidinecarboxylic acid, 2-amino-4-(1,1-dimethylethyl)- (9CI)

Chemical Property:

• PSA: 89.83000
• LogP: 0.98460

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Pyrimidinecarboxylic acid, 2-amino-4-(1,1-dimethylethyl)- (9CI)

There total 2 articles about 5-Pyrimidinecarboxylic acid, 2-amino-4-(1,1-dimethylethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-Amino-4-tert-butyl-pyrimidine-5-carboxylic acid ethyl ester (127957-85-1) → 2-Amino-4-tert-butyl-pyrimidine-5-carboxylic acid (127958-04-7)

Guidance literature:

With potassium hydroxide; In methanol; for 5h; Heating;

Reference yield:

2-dimethylaminomethylene-4,4-dimethyl-3-oxo-pentanoic acid ethyl ester (116344-10-6) → 2-Amino-4-tert-butyl-pyrimidine-5-carboxylic acid (127958-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / NaOEt / ethanol / 2 h / Heating

2: 67 percent / KOH / methanol / 5 h / Heating

With potassium hydroxide; sodium ethanolate; In methanol; ethanol;

Reference yield: 83.0%

2-Amino-4-tert-butyl-pyrimidine-5-carboxylic acid (127958-04-7) → 2-amino-4-(trifluoromethyl)pyrimidine (17321-94-7)

Guidance literature:

for 7h; Heating;

upstream raw materials:

2-Amino-4-tert-butyl-pyrimidine-5-carboxylic acid ethyl ester

2-dimethylaminomethylene-4,4-dimethyl-3-oxo-pentanoic acid ethyl ester

Downstream raw materials:

2-amino-4-(trifluoromethyl)pyrimidine