(1S)-2,2,2-TRIFLUORO-1-(2-PYRIDYL)ETHYLAMINE

Base Information

• Chemical Name: (1S)-2,2,2-TRIFLUORO-1-(2-PYRIDYL)ETHYLAMINE
• CAS No.: 783294-93-9
• Molecular Formula: C₇H₇F₃N₂
• Molecular Weight: 176.141
• Hs Code.: 2933399090
• Mol file: 783294-93-9.mol

Synonyms:(S)-2,2,2-TRIFLUORO-1-PYRIDIN-2-YL-ETHYLAMINE;(1S)-2,2,2-TRIFLUORO-1-(2-PYRIDYL)ETHYLAMINE;(1S)-2,2,2-trifluoro-1-pyridin-2-ylethanamine

Chemical Property of (1S)-2,2,2-TRIFLUORO-1-(2-PYRIDYL)ETHYLAMINE

Chemical Property:

• PSA: 38.91000
• LogP: 2.34400

Purity/Quality:

97% ^*data from raw suppliers

(S)-2,2,2-Trifluoro-1-(pyridin-2-yl)ethanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S)-2,2,2-TRIFLUORO-1-(2-PYRIDYL)ETHYLAMINE

There total 4 articles about (1S)-2,2,2-TRIFLUORO-1-(2-PYRIDYL)ETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

((R)-2,2,2-trifluoro-1-pyridin-2-yl-ethyl)-carbamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (1432507-33-9) → (R)-2,2,2-trifluoro-1-pyridin-2-yl-ethylamine (1228565-87-4,783294-93-9)

Guidance literature:

With trifluorormethanesulfonic acid; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 26h;

Reference yield: 63.0%

((S)-2,2,2-trifluoro-1-pyridin-2-yl-ethyl)-carbamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (1432507-34-0) → (S)-2,2,2-trifluoro-1-pyridin-2-yl-ethylamine (783294-93-9)

Guidance literature:

With trifluorormethanesulfonic acid; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 31h;

Reference yield:

α-(trifluoromethyl)-2-pyridinemethanamine (503173-14-6,783294-93-9) → (R)-2,2,2-trifluoro-1-pyridin-2-yl-ethylamine (1228565-87-4,783294-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4.5 h / 0 °C

1.2: ChiralPak AD

2.1: trifluorormethanesulfonic acid; trifluoroacetic acid / dichloromethane / 26 h / 0 - 20 °C

With trifluorormethanesulfonic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

upstream raw materials:

((S)-2,2,2-trifluoro-1-pyridin-2-yl-ethyl)-carbamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

α-(trifluoromethyl)-2-pyridinemethanamine

((R)-2,2,2-trifluoro-1-pyridin-2-yl-ethyl)-carbamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester