6-O-tert-butyl 2-O-ethyl 6-azaspiro[2.5]octane-2,6-dicarboxylate

Base Information

• Chemical Name: 6-O-tert-butyl 2-O-ethyl 6-azaspiro[2.5]octane-2,6-dicarboxylate
• CAS No.: 1242268-17-2
• Molecular Formula: C₁₅H₂₅NO₄
• Molecular Weight: 283.368
• Hs Code.: 2933990090
• Mol file: 1242268-17-2.mol

Synonyms:6-O-tert-butyl 2-O-ethyl 6-azaspiro[2.5]octane-2,6-dicarboxylate

Chemical Property of 6-O-tert-butyl 2-O-ethyl 6-azaspiro[2.5]octane-2,6-dicarboxylate

Chemical Property:

• Boiling Point: 361.4±35.0 °C(Predicted)
• PKA: -1.18±0.40(Predicted)
• PSA: 55.84000
• Density: 1.12±0.1 g/cm3(Predicted)
• LogP: 2.52460
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

6-tert-Butyl1-Ethyl6-Azaspiro[2.5]octane-1,6-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-O-tert-butyl 2-O-ethyl 6-azaspiro[2.5]octane-2,6-dicarboxylate

There total 1 articles about 6-O-tert-butyl 2-O-ethyl 6-azaspiro[2.5]octane-2,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

trimethylsulfoxonium iodide (1774-47-6) + tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate (135716-08-4) → 6-(tert-butyl) 1-ethyl 6-azaspiro[2.5]octane-1,6-dicarboxylate (1242268-17-2)

Guidance literature:

trimethylsulfoxonium iodide; With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 1.5h;

tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate; In dimethyl sulfoxide; at 20 ℃;

Reference yield: 83.0%

6-(tert-butyl) 1-ethyl 6-azaspiro[2.5]octane-1,6-dicarboxylate (1242268-17-2) → (±)-6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid (871727-05-8)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 15 ℃; for 12h;

Reference yield:

6-(tert-butyl) 1-ethyl 6-azaspiro[2.5]octane-1,6-dicarboxylate (1242268-17-2) → tert-butyl 1-({4-(methoxycarbonyl)-2-[(2-methoxyethyl)amino]phenyl}carbamoyl)-6-azaspiro[2.5]octane-6-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 25 °C

2.1: HATU / N,N-dimethyl-formamide / 0.5 h / 30 °C

2.2: 16 h / 30 °C

With lithium hydroxide monohydrate; water; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

trimethylsulfoxonium iodide

tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate

Downstream raw materials:

(±)-6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid

tert-butyl 1-[[(1S)-1-phenylethyl]carbamoyl]-6-azaspiro[2.5]octane-6-carboxylate

tert-butyl 1-carbamoyl-6-azaspiro[2.5]octane-6-carboxylate

tert-butyl 1-{2-[4-(methanesulfonyl)phenoxy]ethyl}-6-azaspiro[2.5]octane-6-carboxylate