tert-butyl 4-(2-oxo-1,3-oxazinan-3-yl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(2-oxo-1,3-oxazinan-3-yl)piperidine-1-carboxylate
• CAS No.: 1216859-23-2
• Molecular Formula: C₁₄H₂₄N₂O₄
• Molecular Weight: 284.356
• Hs Code.: 2934999090
• Mol file: 1216859-23-2.mol

Synonyms:tert-butyl 4-(2-oxo-1,3-oxazinan-3-yl)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-(dihydro-2-oxo-2H-1,3-oxazin-3(4H)-yl)-, 1,1-dimethylethyl ester

Chemical Property of tert-butyl 4-(2-oxo-1,3-oxazinan-3-yl)piperidine-1-carboxylate

Chemical Property:

• PSA: 59.08000
• LogP: 2.10400

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl 4-(2-oxo-1,3-oxazinan-3-yl)piperidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 4-(2-oxo-1,3-oxazinan-3-yl)piperidine-1-carboxylate

There total 2 articles about tert-butyl 4-(2-oxo-1,3-oxazinan-3-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1'-carbonyldiimidazole (530-62-1) + tert-butyl 4-[(3-hydroxypropyl)amino]piperidine-1-carboxylate (864655-26-5) → tert-butyl 4-(2-oxo-1,3-oxazinan-3-yl)piperidine-1-carboxylate (1216859-23-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; for 72h; Reflux;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 4-(2-oxo-1,3-oxazinan-3-yl)piperidine-1-carboxylate (1216859-23-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / dichloromethane / 3 h / 20 - 27 °C

1.2: 20 - 27 °C / Inert atmosphere

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 72 h / Reflux

With acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane;

upstream raw materials:

1,1'-carbonyldiimidazole

tert-butyl 4-[(3-hydroxypropyl)amino]piperidine-1-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

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