(1R,8S,Z)-8-AMINO-CYCLOOCT-4-ENECARBOXYLIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: (1R,8S,Z)-8-AMINO-CYCLOOCT-4-ENECARBOXYLIC ACID HYDROCHLORIDE
• CAS No.: 795309-10-3
• Molecular Formula: C₉H₁₅NO₂*ClH
• Molecular Weight: 205.685
• Mol file: 795309-10-3.mol

Synonyms:(1R,8S,Z)-8-AMINO-CYCLOOCT-4-ENECARBOXYLIC ACID HYDROCHLORIDE

Chemical Property of (1R,8S,Z)-8-AMINO-CYCLOOCT-4-ENECARBOXYLIC ACID HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 1.15E-05mmHg at 25°C
• Boiling Point: 344.7°C at 760 mmHg
• Flash Point: 162.3°C
• PSA: 63.32000
• LogP: 2.64700

Purity/Quality:

99%min ^*data from raw suppliers

(1R,8S,Z)-8-AMINO-CYCLOOCT-4-ENECARBOXYLIC ACID HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,8S,Z)-8-AMINO-CYCLOOCT-4-ENECARBOXYLIC ACID HYDROCHLORIDE

There total 7 articles about (1R,8S,Z)-8-AMINO-CYCLOOCT-4-ENECARBOXYLIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(1S,8R)-9-hydroxymethyl-9-azabicyclo[6.2.0]dec-4-en-10-one → (Z)-(1S,8R)-8-Amino-cyclooct-4-enecarboxylic acid; hydrochloride (795309-10-3,350015-75-7,795309-08-9)

Guidance literature:

With hydrogenchloride; In water; Reflux;

DOI:10.3390/molecules22122211

Reference yield: 82.0%

(1R*,2S*)-9-azabicyclo[6.2.0]dec-4-en-10-one → (1R*,2S*)-2-aminocyclooct-5-enecarboxylic acid hydrochloride (350015-75-7,795309-10-3,795309-08-9)

Guidance literature:

With hydrogenchloride; water; for 1h; Reflux;

DOI:10.1016/j.tetasy.2010.05.003

Reference yield: 73.0%

(1S,8R,4Z)-9-azabicyclo[6.2.0]dec-4-en-10-one → (Z)-(1S,8R)-8-Amino-cyclooct-4-enecarboxylic acid; hydrochloride (795309-10-3,350015-75-7,795309-08-9)

Guidance literature:

With hydrogenchloride; In water; for 3h; Heating;

DOI:10.1016/j.tetasy.2004.05.029

upstream raw materials:

1,5-cis,cis-cyclooctadiene

Refernces

• 1、 Palko, Marta,Benedek, Gabriella,Forro, Enik,Weber, Edit,Haenninen, Mikko,Sillanpaeae, Reijo,Fueloep, Ferenc. "Synthesis of mono- and dihydroxy-substituted 2-aminocyclooctanecarboxylic acid enantiomers". experimental part. p. 957 - 961. Retrieved 2010/08/06.
• 2、 Forro, Eniko,Arva, Judit,Fueloep, Ferenc. "Preparation of (1R,8S)- and (1S,8R)-9-azabicyclo[6.2.0]dec-4-en-10-one: Potential starting compounds for the synthesis of anatoxin-a". . p. 643 - 649. Retrieved 2007/10/03.