Tolbutamide-d9

Base Information

• Chemical Name: Tolbutamide-d9
• CAS No.: 1219794-57-6
• Molecular Formula: C12H9D9N2O3S
• Molecular Weight: 279.403376002
• Mol file: 1219794-57-6.mol

Synonyms:1-(Butyl-3-(p-tolyl- sulfonyl)urea-d9;3-(p-Tolyl-4-sulfonyl)-1-butylurea-d9;Artosin-d9;Artozin-d9;Mobenol-d9;N-[(ButylaMino-d9)carbonyl]-4-MethylbenzenesulfonaMide;N-Butyl-N'-(4-Methylphenylsulfonyl)urea-d9;Tolylsulfonylbutylurea-d9

Chemical Property of Tolbutamide-d9

Chemical Property:

• Melting Point: 108-111°C
• PSA: 87.14000
• LogP: 3.45750
• Storage Temp.: Refrigerator

Purity/Quality:

97% ^*data from raw suppliers

Tolbutamide-d9 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Tolbutamide-d9 is intended for use as an internal standard for the quantification of tolbutamide by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 μM). It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 μM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets. In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; ). Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.
• Uses: Labelled Tolbutamide (T535150). An antidiabetic, used as a hypoglycemic agent in veterinary medicine.