2-METHYL-5-TRIFLUOROMETHOXY-PHENYLAMINE

Base Information

• Chemical Name: 2-METHYL-5-TRIFLUOROMETHOXY-PHENYLAMINE
• CAS No.: 933674-93-2
• Molecular Formula: C8H8F3NO
• Molecular Weight: 191.153
• Hs Code.: 2922299090

Synonyms:2-METHYL-5-(TRIFLUOROMETHOXY)ANILINE;2-METHYL-5-TRIFLUOROMETHOXY-PHENYLAMINE;86256-59-10

Chemical Property of 2-METHYL-5-TRIFLUOROMETHOXY-PHENYLAMINE

Chemical Property:

• Boiling Point: 209.2±35.0 °C (760 mmHg)
• PSA: 35.25000
• Density: 1.288±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 3.05700
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-5-(trifluoromethoxy)aniline ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-5-TRIFLUOROMETHOXY-PHENYLAMINE

There total 2 articles about 2-METHYL-5-TRIFLUOROMETHOXY-PHENYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

1-methyl-2-nitro-4-(trifluoromethoxy)benzene (70692-45-4) → 2-methyl-5-(trifluoromethoxy)aniline (933674-93-2)

Guidance literature:

With palladium on activated charcoal; ammonium formate; In ethanol; for 0.5h; Reflux;

DOI:10.1021/jm401986p

Reference yield:

p-methyl-α,α,α-trifluoromethoxybenzene (706-27-4) → 2-methyl-5-(trifluoromethoxy)aniline (933674-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; sulfuric acid; nitric acid / 0.5 h / 0 °C

2: ammonium formate; palladium on activated charcoal / ethanol / 0.5 h / Reflux

With sulfuric acid; palladium on activated charcoal; nitric acid; ammonium formate; acetic acid; In ethanol;

DOI:10.1021/jm401986p

Reference yield:

2-methyl-5-(trifluoromethoxy)aniline (933674-93-2) → 4-bromo-2-methyl-5-(trifluoromethoxy)aniline

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice;

DOI:10.1021/jm401986p

upstream raw materials:

1-methyl-2-nitro-4-(trifluoromethoxy)benzene

p-methyl-α,α,α-trifluoromethoxybenzene

Downstream raw materials:

6-trifluoromethoxy-5-(2-trifluoromethylphenyl)-1H-indazole

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