(R)-(3-Bromo-4-methoxy-phenyl)-{[(R)-2-tert-butoxycarbonylamino-2-(3,5-dihydroxy-4-methoxy-phenyl)-ethyl]-methoxycarbonyl-amino}-acetic acid

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Chemical Name:(R)-(3-Bromo-4-methoxy-phenyl)-{[(R)-2-tert-butoxycarbonylamino-2-(3,5-dihydroxy-4-methoxy-phenyl)-ethyl]-methoxycarbonyl-amino}-acetic acid
CAS No.:881392-54-7
Molecular Formula:C₂₅H₃₁BrN₂O₁₀
Molecular Weight:599.433
Hs Code.:

Synonyms:(R)-(3-Bromo-4-methoxy-phenyl)-{[(R)-2-tert-butoxycarbonylamino-2-(3,5-dihydroxy-4-methoxy-phenyl)-ethyl]-methoxycarbonyl-amino}-acetic acid

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Chemical Property of (R)-(3-Bromo-4-methoxy-phenyl)-{[(R)-2-tert-butoxycarbonylamino-2-(3,5-dihydroxy-4-methoxy-phenyl)-ethyl]-methoxycarbonyl-amino}-acetic acid

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Technology Process of (R)-(3-Bromo-4-methoxy-phenyl)-{[(R)-2-tert-butoxycarbonylamino-2-(3,5-dihydroxy-4-methoxy-phenyl)-ethyl]-methoxycarbonyl-amino}-acetic acid

There total 6 articles about (R)-(3-Bromo-4-methoxy-phenyl)-{[(R)-2-tert-butoxycarbonylamino-2-(3,5-dihydroxy-4-methoxy-phenyl)-ethyl]-methoxycarbonyl-amino}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 881392-53-6
(R)-(3-Bromo-4-methoxy-phenyl)-{[(R)-2-tert-butoxycarbonylamino-2-(3,5-dihydroxy-4-methoxy-phenyl)-ethyl]-methoxycarbonyl-amino}-acetic acid methyl ester

: 881392-54-7
(R)-(3-Bromo-4-methoxy-phenyl)-{[(R)-2-tert-butoxycarbonylamino-2-(3,5-dihydroxy-4-methoxy-phenyl)-ethyl]-methoxycarbonyl-amino}-acetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1021/ja0572912

Reference yield:

: 881392-52-5
(R)-{[(R)-2-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-2-tert-butoxycarbonylamino-ethyl]-methoxycarbonyl-amino}-(3-bromo-4-methoxy-phenyl)-acetic acid methyl ester

: 881392-54-7
(R)-(3-Bromo-4-methoxy-phenyl)-{[(R)-2-tert-butoxycarbonylamino-2-(3,5-dihydroxy-4-methoxy-phenyl)-ethyl]-methoxycarbonyl-amino}-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / H₂ / Raney-Ni / methanol / 5 h / 0 °C

2: 100 percent / aq. LiOH / tetrahydrofuran / 2 h / 0 °C

With lithium hydroxide; hydrogen; nickel; In tetrahydrofuran; methanol;
DOI:10.1021/ja0572912

Reference yield:

: 881392-49-0
[1-(3,5-bis-benzyloxy-4-methoxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

: 881392-54-7
(R)-(3-Bromo-4-methoxy-phenyl)-{[(R)-2-tert-butoxycarbonylamino-2-(3,5-dihydroxy-4-methoxy-phenyl)-ethyl]-methoxycarbonyl-amino}-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3 Angstroem molecular sieves / methanol / 1 h / 0 °C

1.2: 19.40 g / NaBCNH₃; AcOH / methanol / 48 h / -20 °C / pH 6

2.1: 85 percent / K₂CO₃ / tetrahydrofuran / 18 h / 25 °C

3.1: 98 percent / H₂ / Raney-Ni / methanol / 5 h / 0 °C

4.1: 100 percent / aq. LiOH / tetrahydrofuran / 2 h / 0 °C

With lithium hydroxide; 3 A molecular sieve; hydrogen; potassium carbonate; nickel; In tetrahydrofuran; methanol;
DOI:10.1021/ja0572912