6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid ethyl ester

Base Information

• Chemical Name: 6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid ethyl ester
• CAS No.: 479490-65-8
• Molecular Formula: C₂₁H₂₇NO₆
• Molecular Weight: 389.448

Synonyms:6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid ethyl ester

Chemical Property of 6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid ethyl ester

There total 2 articles about 6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one (103201-79-2,1820583-17-2) → 6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid ethyl ester (479490-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaN(TMS)2 / tetrahydrofuran / 1.5 h / -5 - 0 °C

2: tetrahydrofuran / 1.5 h / 20 °C

With sodium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1021/jo020433f

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) + Sodium; ethoxy-[(3R,7aS)-5-oxo-3-phenyl-dihydro-pyrrolo[1,2-c]oxazol-(6E)-ylidene]-methanolate → 6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid ethyl ester (479490-65-8)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 1.5h;

DOI:10.1021/jo020433f

Reference yield:

6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid ethyl ester (479490-65-8) → 6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid (479490-43-2)

Guidance literature:

With sodium hydroxide; In acetonitrile; at 20 ℃; for 18h;

DOI:10.1021/jo020433f

upstream raw materials:

bromoacetic acid tert-butyl ester

(3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

Downstream raw materials:

6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid

(2R,5S,7S)-7-(tert-butyloxycarbonylmethyl)-8-oxo-2-phenyl-1-aza-3-oxa-bicyclo[3.3.0]octane

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