EPTAPIRONE

Base Information

Chemical Name:EPTAPIRONE
CAS No.:179756-58-2
Molecular Formula:C16H23N7O2
Molecular Weight:345.405
Hs Code.:
Mol file:179756-58-2.mol

Synonyms:

Suppliers and Price of EPTAPIRONE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Eptapirone
10mg
$ 175.00

DC Chemicals
Eptapirone >98%
1 g
$ 1700.00

DC Chemicals
Eptapirone >98%
250 mg
$ 800.00

ChemScene
Eptapirone 99.91%
5mg
$ 105.00

ChemScene
Eptapirone 99.91%
10mg
$ 175.00

ChemScene
Eptapirone 99.91%
50mg
$ 635.00

Cayman Chemical
Eptapirone ≥98%
10mg
$ 247.00

Cayman Chemical
Eptapirone ≥98%
25mg
$ 508.00

Cayman Chemical
Eptapirone ≥98%
5mg
$ 131.00

Cayman Chemical
Eptapirone ≥98%
1mg
$ 29.00

Total 13 raw suppliers

Chemical Property of EPTAPIRONE

Chemical Property:

Boiling Point:517.4±60.0 °C(Predicted)
PKA:7.72±0.10(Predicted)
Density:1.35±0.1 g/cm3(Predicted)
Storage Temp.:Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Eptapirone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Eptapirone is a potent agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 4.8 nM in a radioligand binding assay). It is selective for 5-HT1A over other 5-HT receptor subtypes, dopamine D2 receptors, α1-adrenergic receptors, and histamine H1 receptors (Kis = <10,000, 1,770, 691.8, and <10,000 nM, respectively). Eptapirone inhibits cAMP stimulation induced by forskolin in HA7 cells transfected with human 5-HT1A receptors (EC50 = 158 nM). In vivo, eptapirone increases extracellular 5-HT in the ventral hippocampus of rats (ED50 = 0.049 mg/kg) and serum corticosterone levels when administered p.o. or i.p. (ED50s = 0.16 and 0.057 mg/kg, respectively). It decreases immobility in rats in a forced swim test and increases punished responding in a pigeon conflict procedure, demonstrating antidepressant-like and anxiolytic activity. Eptapirone (2.5 mg/kg, p.o.) also attenuates hypertension and tachycardia induced by sibutramine in rats with no effect on sibutramine-induced hypophagia.
Uses Eptapirone is 5-HT1A receptor agonist with anxiolytic and antidepressant potential.

Technology Process of EPTAPIRONE

There total 3 articles about EPTAPIRONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.6%

: 179756-87-7
2-(4-chlorobutyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione

: 78069-54-2,94021-22-4,123319-76-6
1-(2-pyrimidinyl)piperazine hydrochloride

: 179756-58-2
Eptapirone

Guidance literature:: 2-(4-chlorobutyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione; With sodium iodide; In acetonitrile; at 60 ℃; for 1h;

1-(2-pyrimidinyl)piperazine hydrochloride; With potassium carbonate; at 50 ℃;

Reference yield:

: 179756-87-7
2-(4-chlorobutyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione

: 20980-22-7
N-(2-pyridinyl)piperazine

: 179756-58-2
Eptapirone

Guidance literature:: 2-(4-chlorobutyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione; With sodium iodide; In acetonitrile; for 0.5h; Reflux;

N-(2-pyridinyl)piperazine; With potassium carbonate; In acetonitrile; at 60 ℃; for 24h;
DOI:10.1016/j.bmcl.2014.07.048