1'-acetyl-3'-benzyl-2',3'-dihydrospiroindol>-3'-ol

Base Information

Chemical Name:1'-acetyl-3'-benzyl-2',3'-dihydrospiroindol>-3'-ol
CAS No.:79697-22-6
Molecular Formula:C₁₉H₁₉NO₂
Molecular Weight:293.365
Hs Code.:

1'-acetyl-3'-benzyl-2',3'-dihydrospiro<cyclopropane-1,2'-<2H>indol>-3'-ol

Synonyms:1'-acetyl-3'-benzyl-2',3'-dihydrospiroindol>-3'-ol

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Chemical Property of 1'-acetyl-3'-benzyl-2',3'-dihydrospiroindol>-3'-ol

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Technology Process of 1'-acetyl-3'-benzyl-2',3'-dihydrospiroindol>-3'-ol

There total 4 articles about 1'-acetyl-3'-benzyl-2',3'-dihydrospiroindol>-3'-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1589-82-8
phenylmagnesium bromide

: 64053-80-1
1'-acetylspiroindol>-3'(1'H)-one

: 79697-22-6
1'-acetyl-3'-benzyl-2',3'-dihydrospiroindol>-3'-ol

Guidance literature:: With magnesium; In tetrahydrofuran; diethyl ether; at 0 - 4 ℃; for 15h;
DOI:10.1248/cpb.29.1900

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 79697-22-6
1'-acetyl-3'-benzyl-2',3'-dihydrospiroindol>-3'-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / Na₂CO₃ / H₂O / RT, 1 h, 40/50 deg C, 8 h

2: 91 percent / Et₃N / 3 h / 130 °C

3: 94 percent / NaCl / dimethylsulfoxide / 2 h / 155 - 160 °C

4: 79 percent / Mg / tetrahydrofuran; diethyl ether / 15 h / 0 - 4 °C

With sodium carbonate; magnesium; triethylamine; sodium chloride; In tetrahydrofuran; diethyl ether; water; dimethyl sulfoxide;
DOI:10.1248/cpb.29.1900

Reference yield:

: 64054-23-5
2-<(tetrahidro-2-oxo-3-furanyl)amino>benzoic acid

: 79697-22-6
1'-acetyl-3'-benzyl-2',3'-dihydrospiroindol>-3'-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / Et₃N / 3 h / 130 °C

2: 94 percent / NaCl / dimethylsulfoxide / 2 h / 155 - 160 °C

3: 79 percent / Mg / tetrahydrofuran; diethyl ether / 15 h / 0 - 4 °C

With magnesium; triethylamine; sodium chloride; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1248/cpb.29.1900