N-(2,4-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

Base Information

Chemical Name:N-(2,4-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide
CAS No.:1617521-89-7
Molecular Formula:C₁₉H₁₇F₂N₃O₃
Molecular Weight:373.359
Hs Code.:

Synonyms:N-(2,4-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

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Chemical Property of N-(2,4-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

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Technology Process of N-(2,4-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

There total 4 articles about N-(2,4-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1177228-47-5
C₁₃H₁₄N₂O₄

: 367-25-9,76563-56-9
2,4-difluorophenylamine

: 1617521-89-7
N-(2,4-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 23 ℃; for 18h;

Reference yield:

: 1222174-92-6
5-bromo-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester

: 1617521-89-7
N-(2,4-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 1.5 h / 100 °C / Microwave irradiation

2: lithium hydroxide; water / 1,4-dioxane / 1 h / 70 °C

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 23 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 1: |Suzuki Coupling;

Reference yield:

: 51985-95-6
methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate

: 1617521-89-7
N-(2,4-difluoro-phenyl)-5-(2,5-dimethoxyphenyl)-1-methyl-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus(V) oxybromide / acetonitrile / 18 h / 80 °C

2: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 1.5 h / 100 °C / Microwave irradiation

3: lithium hydroxide; water / 1,4-dioxane / 1 h / 70 °C

4: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 23 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; phosphorus(V) oxybromide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile; 2: |Suzuki Coupling;