N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide trifluoroacetic acid

Base Information

Chemical Name:N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide trifluoroacetic acid
CAS No.:1228652-98-9
Molecular Formula:C₂HF₃O₂*C₁₃H₁₄F₃N₃O₂
Molecular Weight:415.292
Hs Code.:

Synonyms:N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide trifluoroacetic acid

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Chemical Property of N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide trifluoroacetic acid

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Technology Process of N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide trifluoroacetic acid

There total 3 articles about N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1228652-17-2
3-[2-(3-trifluoro-methyl-benzoylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 1228652-98-9
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide trifluoroacetic acid

Guidance literature:: In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2011.06.080

Reference yield:

: 1228652-17-2
3-[2-(3-trifluoro-methyl-benzoylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butyl ester

: 1228652-98-9
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide trifluoroacetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 17794-48-8
m-trifluoromethylhippuric acid

: 1228652-98-9
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide trifluoroacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

2: dichloromethane / 2 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.bmcl.2011.06.080