(R)-tert-butyl 4-(2-isopropylpent-4-enamido)phenylcarbamate

Base Information

• Chemical Name: (R)-tert-butyl 4-(2-isopropylpent-4-enamido)phenylcarbamate
• CAS No.: 1391831-30-3
• Molecular Formula: C₁₈H₂₆N₂O₃
• Molecular Weight: 318.416
• Mol file: 1391831-30-3.mol

Synonyms:(R)-tert-butyl 4-(2-isopropylpent-4-enamido)phenylcarbamate

Chemical Property of (R)-tert-butyl 4-(2-isopropylpent-4-enamido)phenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 4-(2-isopropylpent-4-enamido)phenylcarbamate

There total 2 articles about (R)-tert-butyl 4-(2-isopropylpent-4-enamido)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

N-(tert-butoxycarbonyl)-1,4-phenylenediamine (71026-66-9) + (S)-2-ethylpent-4-enoic acid (393563-10-5) → (R)-tert-butyl 4-(2-isopropylpent-4-enamido)phenylcarbamate (1391831-30-3)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1002/ejoc.201200147

Reference yield:

(4R,5S)-3-[(2S)-1-oxo-2-ethyl-4-pentenyl]-4-methyl-5-phenyl-2-oxazolidinone (121074-25-7,121074-20-2) → (R)-tert-butyl 4-(2-isopropylpent-4-enamido)phenylcarbamate (1391831-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 0 - 20 °C

1.2: pH 1

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

With dmap; dihydrogen peroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1002/ejoc.201200147

upstream raw materials:

N-(tert-butoxycarbonyl)-1,4-phenylenediamine

(S)-2-ethylpent-4-enoic acid

(4R,5S)-3-[(2S)-1-oxo-2-ethyl-4-pentenyl]-4-methyl-5-phenyl-2-oxazolidinone