3N-({1-[2-(4-hydroxyphenyl)ethyl]hexahydro-4-pyridinyl}methyl)-2-methyl-2H-3-indazolecarboxamide hydrochloride

Base Information

Chemical Name:3N-({1-[2-(4-hydroxyphenyl)ethyl]hexahydro-4-pyridinyl}methyl)-2-methyl-2H-3-indazolecarboxamide hydrochloride
CAS No.:1029643-59-1
Molecular Formula:C₂₃H₂₈N₄O₂*ClH
Molecular Weight:428.962
Hs Code.:

Synonyms:3N-({1-[2-(4-hydroxyphenyl)ethyl]hexahydro-4-pyridinyl}methyl)-2-methyl-2H-3-indazolecarboxamide hydrochloride

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Chemical Property of 3N-({1-[2-(4-hydroxyphenyl)ethyl]hexahydro-4-pyridinyl}methyl)-2-methyl-2H-3-indazolecarboxamide hydrochloride

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Technology Process of 3N-({1-[2-(4-hydroxyphenyl)ethyl]hexahydro-4-pyridinyl}methyl)-2-methyl-2H-3-indazolecarboxamide hydrochloride

There total 6 articles about 3N-({1-[2-(4-hydroxyphenyl)ethyl]hexahydro-4-pyridinyl}methyl)-2-methyl-2H-3-indazolecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1-(2-(4-hydroxyphenyl)ethyl)-4-piperidinylmethanamine

: 181071-92-1
2-methyl-2H-indazole-3-carbonyl chloride

: 1029643-59-1
3N-({1-[2-(4-hydroxyphenyl)ethyl]hexahydro-4-pyridinyl}methyl)-2-methyl-2H-3-indazolecarboxamide hydrochloride

Guidance literature:: 1-(2-(4-hydroxyphenyl)ethyl)-4-piperidinylmethanamine; 2-methyl-2H-indazole-3-carbonyl chloride; In toluene; at 25 ℃; for 12h;

With hydrogenchloride; In ethanol;
DOI:10.1002/cmdc.201800199

Reference yield:

: 1029644-02-7
N₃-((1-(2-(4-hydroxyphenyl)ethyl)hexahydro-4-pyridinyl)methyl)-2-methyl-2H-3-indazolecarboxamide

: 1029643-59-1
3N-({1-[2-(4-hydroxyphenyl)ethyl]hexahydro-4-pyridinyl}methyl)-2-methyl-2H-3-indazolecarboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; ethyl acetate; at 20 ℃; for 3h;

Reference yield:

: 7144-05-0
4-Aminomethylpiperidine

: 1029643-59-1
3N-({1-[2-(4-hydroxyphenyl)ethyl]hexahydro-4-pyridinyl}methyl)-2-methyl-2H-3-indazolecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 3 h / 25 °C

2: potassium carbonate / ethanol / 24 h / Reflux

3: water; hydrogenchloride / 2 h / 25 °C

4: toluene / 12 h / 25 °C

With hydrogenchloride; water; potassium carbonate; In ethanol; toluene;
DOI:10.1002/cmdc.201800199