N-{(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propyl}-2,4,6-trifluoro-benzamide

Base Information

• Chemical Name: N-{(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propyl}-2,4,6-trifluoro-benzamide
• CAS No.: 724733-67-9
• Molecular Formula: C₂₈H₃₄BrF₃N₄O₆
• Molecular Weight: 659.5
• Mol file: 724733-67-9.mol

Synonyms:N-{(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propyl}-2,4,6-trifluoro-benzamide

Chemical Property of N-{(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propyl}-2,4,6-trifluoro-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propyl}-2,4,6-trifluoro-benzamide

There total 9 articles about N-{(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propyl}-2,4,6-trifluoro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

(S)-2-((S)-2-aminopropanoylamino)-4-methylpentanoic acid amide (38689-32-6) + 2,4,6-trifluorobenzoic acid (28314-80-9) + (3S,4S)-4-azido-5-(4-bromobenzyloxy)-3-hydroxypentanoic acid methyl ester (724733-51-1) → N-{(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propyl}-2,4,6-trifluoro-benzamide (724733-67-9)

Guidance literature:

Multistep reaction;

DOI:10.1021/jm031106i

Reference yield:

H-L-Leu-NH2 (687-51-4,13079-20-4,13366-40-0,15893-47-7) → N-{(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propyl}-2,4,6-trifluoro-benzamide (724733-67-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-hydroxy-7-azabenzotriazole; 1,8-bis(N,N-dimethylamino)naphthalene; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / dimethylformamide / 0 - 20 °C

2: 100 percent / H₂ / Pd/C / aq. ethanol / 1.5 h / atmospheric pressure

With 1-hydroxy-7-aza-benzotriazole; hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm031106i

Reference yield:

Z-(S)-Ala-(S)-Leu-NH2 (18323-56-3) → N-{(1S,2S)-1-(4-Bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propyl}-2,4,6-trifluoro-benzamide (724733-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / aq. ethanol / 1.5 h / atmospheric pressure

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm031106i

upstream raw materials:

(S)-2-((S)-2-aminopropanoylamino)-4-methylpentanoic acid amide

2,4,6-trifluorobenzoic acid

(3S,4S)-4-azido-5-(4-bromobenzyloxy)-3-hydroxypentanoic acid methyl ester

H-L-Leu-NH₂