3-[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-(hydroxymethyl)-2-oxopyridin-1 (2H)-yl]-4-methylbenzoic acid

Base Information

Chemical Name:3-[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-(hydroxymethyl)-2-oxopyridin-1 (2H)-yl]-4-methylbenzoic acid
CAS No.:586381-87-5
Molecular Formula:C₂₁H₁₆BrF₂NO₅
Molecular Weight:480.263
Hs Code.:

Synonyms:3-[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-(hydroxymethyl)-2-oxopyridin-1 (2H)-yl]-4-methylbenzoic acid

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Chemical Property of 3-[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-(hydroxymethyl)-2-oxopyridin-1 (2H)-yl]-4-methylbenzoic acid

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Technology Process of 3-[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-(hydroxymethyl)-2-oxopyridin-1 (2H)-yl]-4-methylbenzoic acid

There total 4 articles about 3-[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-(hydroxymethyl)-2-oxopyridin-1 (2H)-yl]-4-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 847139-87-1
C₂₂H₁₈BrF₂NO₅

: 586381-87-5
3-[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-(hydroxymethyl)-2-oxopyridin-1 (2H)-yl]-4-methylbenzoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1016/j.bmcl.2011.04.121

Reference yield:

: 586381-85-3
C₁₇H₁₇NO₆

: 586381-87-5
3-[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-(hydroxymethyl)-2-oxopyridin-1 (2H)-yl]-4-methylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / acetonitrile

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C

3: potassium carbonate / methanol / 24 h / 25 °C

4: sodium hydroxide / tetrahydrofuran / 6 h / 20 °C

With N-Bromosuccinimide; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2011.04.121

Reference yield:

: 586381-83-1
C₂₄H₂₀BrF₂NO₆

: 586381-87-5
3-[3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-(hydroxymethyl)-2-oxopyridin-1 (2H)-yl]-4-methylbenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 24 h / 25 °C

2: sodium hydroxide / tetrahydrofuran / 6 h / 20 °C

With potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2011.04.121