3-p-Tolyl-acryloyl azide

Base Information

• Chemical Name: 3-p-Tolyl-acryloyl azide
• CAS No.: 24186-38-7
• Molecular Formula: C₁₀H₉N₃O
• Molecular Weight: 187.201
• Mol file: 24186-38-7.mol

Synonyms:3-p-Tolyl-acryloyl azide;SCHEMBL14416201;IFVSVRKWJLKNIT-UHFFFAOYSA-N;AKOS030255477;FT-0671618

Chemical Property of 3-p-Tolyl-acryloyl azide

Chemical Property:

• Melting Point: 71-73 °C (decomp)
• Solubility.: Ethyl Acetate, Methanol
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 187.074561919
• Heavy Atom Count: 14
• Complexity: 271

Purity/Quality:

98%,99%, ^*data from raw suppliers

p-Methyl-cinnamoyl azide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C=CC(=O)N=[N+]=[N-]
• Uses: p-Methyl-cinnamoyl Azide (cas# 24186-38-7) is a compound useful in organic synthesis.

Technology Process of 3-p-Tolyl-acryloyl azide

There total 2 articles about 3-p-Tolyl-acryloyl azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-methylcinnamic acid (1866-39-3,940-61-4) → C10H9N3O (24186-38-7)

Guidance literature:

With sodium azide; bis-[(trifluoroacetoxy)iodo]benzene; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2009.06.097

Reference yield: 85.0%

p-methylcinnamoyl benzotriazolyl amide (895160-08-4) → C10H9N3O (24186-38-7)

Guidance literature:

With sodium azide; iron(III) chloride hexahydrate; In water; acetone; at 20 ℃; for 1.08333h;

DOI:10.1080/00397911.2010.505698

Reference yield: 84.5%

1,2,3-Benzotriazole (95-14-7,27556-51-0) + C10H9N3O (24186-38-7) → C16H14N4O

Guidance literature:

In toluene; at 70 - 80 ℃; for 1h;

DOI:10.1055/s-0029-1217820

upstream raw materials:

4-methylcinnamic acid

p-methylcinnamoyl benzotriazolyl amide

Downstream raw materials:

7-methylisoquinolin-1(2H)-one

Refernces

• 1、 Telvekar, Vikas N.,Takale, Balaram S.,Bachhav, Harshal M.. "Simple and facile method for the preparation of vinyl azides". scheme or table. p. 5056 - 5058. Retrieved 2009/12/05.