deux références: JFP452-1 et JFP456b

Base Information

• Chemical Name: deux références: JFP452-1 et JFP456b
• CAS No.: 137038-63-2
• Molecular Formula: C₁₂H₁₃N₃O₂
• Molecular Weight: 231.254
• Mol file: 137038-63-2.mol

Synonyms:deux références: JFP452-1 et JFP456b

Chemical Property of deux références: JFP452-1 et JFP456b

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of deux références: JFP452-1 et JFP456b

There total 18 articles about deux références: JFP452-1 et JFP456b which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(S)-2-((S)-1-Azido-2-phenyl-ethyl)-5-methoxy-tetrahydro-furan → deux références: JFP452-1 et JFP456b (137038-63-2)

Guidance literature:

With boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 3h;

DOI:10.1021/jo00023a009

Reference yield: 34.0%

(5S,1'R)-5-(1'-bromo-2'-phenylethyl)dihydrofuran-2(3H)-one (145761-25-7) → deux références: JFP452-1 et JFP456b (137038-63-2)

Guidance literature:

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium azide; Ambient temperature;

DOI:10.1039/c39920001562

Reference yield:

D-Mannose (530-26-7) → deux références: JFP452-1 et JFP456b (137038-63-2)

Guidance literature:

Multi-step reaction with 10 steps

1: 3percent H₂SO₄ / 12 h / 23 °C

2: 1) CCl₄, (Me₂N)3P, 2) Li, NH₃ / 1a) THF, -78 deg C, 30 min, b) 23 deg C, 30 min, 2) -78 deg C to 0 deg C, 5 h

3: 97 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 12 h / 0 deg C to 23 deg C

4: H₂ / 10percent Pd-C / ethyl acetate; methanol / 5 h

5: 84 percent / 40percent aq. AcOH / 3 h / 90 °C

6: pyridine / 12 h / 0 deg C to 23 deg C

7: NaOMe / CHCl₃ / 1) 0 deg C, 10 min, 2) 23 deg C, 4 h

8: 91 percent / CuI / tetrahydrofuran / 3 h / -40 deg C to 0 deg C

9: 92 percent / Ph₃P, EtO₂CN=NCO₂Et, Ph₂P(O)N₃ / toluene / 12 h / -10 deg C to 23 deg C

10: 72 percent / m-chloroperbenzoic acid, BF₃*OEt₂ / CH₂Cl₂ / 3 h / 0 °C

With pyridine; tetrachloromethane; copper(l) iodide; sulfuric acid; boron trifluoride diethyl etherate; diphenylphosphoranyl azide; ammonia; hydrogen; sodium methylate; pyridinium p-toluenesulfonate; lithium; acetic acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; Hexamethylphosphorous triamide; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate; toluene;

DOI:10.1021/jo00023a009

upstream raw materials:

(5S,1'R)-5-(1'-bromo-2'-phenylethyl)dihydrofuran-2(3H)-one

(2S)-tetrahydro-5-oxofuran-2-carboxylic acid

(5S,1'S)-5-(1'-hydroxy-2'-phenylethyl)dihydrofuran-2(3H)-one

(5S,1'S)-5-(1'-methanesulfonyloxy-2'-phenylethyl)dihydrofuran-2(3H)-one

Downstream raw materials:

(3S,5S)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one

(2R,4S,5S)-N,2-dibenzyl-5-[(tert-butoxycarbonyl)amino]-4-hydroxy-6-phenylhexanamide

(3R,5S)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one

tert-butyl (1S)-1-[(2S)-5-oxotetrahydrofuran-2-yl]-2-phenylethylcarbamate