(2S,7R,E)-ethyl 2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnon-4-enoate

Base Information

Chemical Name:(2S,7R,E)-ethyl 2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnon-4-enoate
CAS No.:387353-70-0
Molecular Formula:C₂₇H₄₄O₅
Molecular Weight:448.643
Hs Code.:

Synonyms:(2S,7R,E)-ethyl 2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnon-4-enoate

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Chemical Property of (2S,7R,E)-ethyl 2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnon-4-enoate

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Technology Process of (2S,7R,E)-ethyl 2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnon-4-enoate

There total 34 articles about (2S,7R,E)-ethyl 2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnon-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1345836-59-0
(S)-ethyl 2-isopropyl-4-oxobutanoate

: C₂₅H₃₄N₄O₅S

: 387353-70-0
(2S,7R,E)-ethyl 2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnon-4-enoate

Guidance literature:: C₂₅H₃₄N₄O₅S; With potassium hexamethylsilazane; In 1,2-dimethoxyethane; at -78 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

(S)-ethyl 2-isopropyl-4-oxobutanoate; In 1,2-dimethoxyethane; at -78 - -60 ℃; for 3h; Schlenk technique; Inert atmosphere;
DOI:10.1002/chem.201406523

Reference yield:

: 172900-75-3
4-methoxy-3-(3-methoxypropoxy)benzaldehyde

: 387353-70-0
(2S,7R,E)-ethyl 2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnon-4-enoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 30 °C

1.2: pH 2

2.1: phosphorus tribromide / dichloromethane / 2.17 h / 0 - 5 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere

3.2: -70 - 5 °C

4.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 30 °C

5.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere

5.2: 5.75 h / 0 - 30 °C

6.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C

7.1: magnesium; ethylene dibromide / tetrahydrofuran / 4.17 h / 63 - 68 °C / Inert atmosphere

7.2: 12.5 h / 0 - 5 °C

With sodium tetrahydroborate; N-chloro-succinimide; lithium hydroxide monohydrate; dihydrogen peroxide; phosphorus tribromide; magnesium; ethylene dibromide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 172900-71-9
(R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid

: 387353-70-0
(2S,7R,E)-ethyl 2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnon-4-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere

1.2: 5.75 h / 0 - 30 °C

2.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C

3.1: magnesium; ethylene dibromide / tetrahydrofuran / 4.17 h / 63 - 68 °C / Inert atmosphere

3.2: 12.5 h / 0 - 5 °C

With sodium tetrahydroborate; N-chloro-succinimide; magnesium; ethylene dibromide; triphenylphosphine; In tetrahydrofuran; dichloromethane;