(4R)-4-(3,4-dimethoxyphenyl)-4-[(2-phenylmethoxy)ethyl]cyclohex-2-enole

Base Information

Chemical Name:(4R)-4-(3,4-dimethoxyphenyl)-4-[(2-phenylmethoxy)ethyl]cyclohex-2-enole
CAS No.:321351-50-2
Molecular Formula:C₂₃H₂₈O₄
Molecular Weight:368.473
Hs Code.:

Synonyms:(4R)-4-(3,4-dimethoxyphenyl)-4-[(2-phenylmethoxy)ethyl]cyclohex-2-enole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R)-4-(3,4-dimethoxyphenyl)-4-[(2-phenylmethoxy)ethyl]cyclohex-2-enole

Chemical Property:

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Technology Process of (4R)-4-(3,4-dimethoxyphenyl)-4-[(2-phenylmethoxy)ethyl]cyclohex-2-enole

There total 7 articles about (4R)-4-(3,4-dimethoxyphenyl)-4-[(2-phenylmethoxy)ethyl]cyclohex-2-enole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 321351-49-9
(4R)-4-(3,4-dimethoxyphenyl)-4-[(2-phenylmethoxy)ethyl]cyclohex-2-enone

: 321351-50-2
(4R)-4-(3,4-dimethoxyphenyl)-4-[(2-phenylmethoxy)ethyl]cyclohex-2-enole

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 0.333333h;
DOI:10.1021/jo001237g

Reference yield:

: 2859-78-1
4-Bromoveratrole

: 321351-50-2
(4R)-4-(3,4-dimethoxyphenyl)-4-[(2-phenylmethoxy)ethyl]cyclohex-2-enole

Guidance literature:: Multi-step reaction with 7 steps

1.1: Mg / tetrahydrofuran

1.2: 94 percent / CuBr-Me₂S; Me₂S / tetrahydrofuran / 0.17 h / -15 °C

2.1: 96 percent / 30percent H₂O₂; LiOH*H₂O / H₂O; tetrahydrofuran / 2 h / 0 °C

3.1: 89 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

4.1: NaH / dimethylformamide / 0.5 h / 20 °C

4.2: 84 percent / 17 h / 20 °C

5.1: 85 percent / KHMDS / diethyl ether; toluene / 17 h / 20 °C

6.1: O₃ / CH₂Cl₂ / -78 °C

6.2: PPh₃ / 17 h / -78 - 20 °C

6.3: 83 percent / p-TsOH*H₂O / benzene / 4 h / Heating

7.1: 87 percent / LiAlH₄ / tetrahydrofuran / 0.33 h / 20 °C

With lithium hydroxide; lithium aluminium tetrahydride; potassium hexamethylsilazane; sodium hydride; ozone; magnesium; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo001237g

Reference yield:

: 321351-46-6
(3R)-7-chloro-3-(3,4-dimethoxyphenyl)-6-methylhept-6-en-1-ol

: 321351-50-2
(4R)-4-(3,4-dimethoxyphenyl)-4-[(2-phenylmethoxy)ethyl]cyclohex-2-enole

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 84 percent / 17 h / 20 °C

2.1: 85 percent / KHMDS / diethyl ether; toluene / 17 h / 20 °C

3.1: O₃ / CH₂Cl₂ / -78 °C

3.2: PPh₃ / 17 h / -78 - 20 °C

3.3: 83 percent / p-TsOH*H₂O / benzene / 4 h / Heating

4.1: 87 percent / LiAlH₄ / tetrahydrofuran / 0.33 h / 20 °C

With lithium aluminium tetrahydride; potassium hexamethylsilazane; sodium hydride; ozone; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo001237g