Boc-D-Phe-Pro-Lys(Boc)Ψ[CHOHCO]-OMe

Base Information

Chemical Name:Boc-D-Phe-Pro-Lys(Boc)Ψ[CHOHCO]-OMe
CAS No.:474081-24-8
Molecular Formula:C₃₂H₅₀N₄O₉
Molecular Weight:634.77
Hs Code.:

Synonyms:Boc-D-Phe-Pro-Lys(Boc)Ψ[CHOHCO]-OMe

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Chemical Property of Boc-D-Phe-Pro-Lys(Boc)Ψ[CHOHCO]-OMe

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Technology Process of Boc-D-Phe-Pro-Lys(Boc)Ψ[CHOHCO]-OMe

There total 8 articles about Boc-D-Phe-Pro-Lys(Boc)Ψ[CHOHCO]-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 474081-24-8
Boc-D-Phe-Pro-Lys(Boc)Ψ[CHOHCO]-OMe

Guidance literature:: Multi-step reaction with 3 steps

1.1: 15.8 g / Et₃N / dimethylformamide / 20 °C / pH 8

2.1: H₂; aq. HCl / 10percent Pd/C / dimethylformamide / 2 h / 20 °C

3.1: HOBt / dimethylformamide / 1 h / 0 °C

3.2: 511 mg / Et₃N / dimethylformamide / 16 h / 0 - 20 °C / pH 8

With hydrogenchloride; hydrogen; benzotriazol-1-ol; triethylamine; 10percent Pd/C; In N,N-dimethyl-formamide;
DOI:10.1021/jm011110z

Reference yield:

: 2389-60-8
Z-Lys(Boc)-OH

: 474081-24-8
Boc-D-Phe-Pro-Lys(Boc)Ψ[CHOHCO]-OMe

Guidance literature:: Multi-step reaction with 7 steps

1.1: 99 percent / TBTU; Et₃N / CH₂Cl₂ / 2 h / 20 °C / pH 8

2.1: DiBAL-H / CH₂Cl₂; hexane / 1 h / -78 °C

3.1: 26.3 g / aq. triethylbenzylammonium chloride / CH₂Cl₂

4.1: HCl / diethyl ether / -20 - 4 °C

4.2: water / diethyl ether / 16 h / 5 - 20 °C

5.1: 15.8 g / Et₃N / dimethylformamide / 20 °C / pH 8

6.1: H₂; aq. HCl / 10percent Pd/C / dimethylformamide / 2 h / 20 °C

7.1: HOBt / dimethylformamide / 1 h / 0 °C

7.2: 511 mg / Et₃N / dimethylformamide / 16 h / 0 - 20 °C / pH 8

With hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; diisobutylaluminium hydride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; 10percent Pd/C; In diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm011110z

Reference yield:

: 2389-49-3
N^α-(benzyloxycarbonyl)-N^ε-(tert-butoxycarbonyl)-L-lysine methyl ester

: 474081-24-8
Boc-D-Phe-Pro-Lys(Boc)Ψ[CHOHCO]-OMe

Guidance literature:: Multi-step reaction with 6 steps

1.1: DiBAL-H / CH₂Cl₂; hexane / 1 h / -78 °C

2.1: 26.3 g / aq. triethylbenzylammonium chloride / CH₂Cl₂

3.1: HCl / diethyl ether / -20 - 4 °C

3.2: water / diethyl ether / 16 h / 5 - 20 °C

4.1: 15.8 g / Et₃N / dimethylformamide / 20 °C / pH 8

5.1: H₂; aq. HCl / 10percent Pd/C / dimethylformamide / 2 h / 20 °C

6.1: HOBt / dimethylformamide / 1 h / 0 °C

6.2: 511 mg / Et₃N / dimethylformamide / 16 h / 0 - 20 °C / pH 8

With hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; diisobutylaluminium hydride; benzotriazol-1-ol; triethylamine; 10percent Pd/C; In diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm011110z